Khan Raees, Shah Muhammad Dawood, Shah Luqman, Lee Ping-Chin, Khan Imran
Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan.
Borneo Marine Research Institute, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.
Front Nutr. 2022 Nov 3;9:1031935. doi: 10.3389/fnut.2022.1031935. eCollection 2022.
Bacterial polysaccharides are unique due to their higher purity, hydrophilic nature, and a finer three-dimensional fibrous structure. Primarily, these polymers provide protection, support, and energy to the microorganism, however, more recently several auxiliary properties of these biopolymers have been unmasked. Microbial polysaccharides have shown therapeutic abilities against various illnesses, augmented the healing abilities of the herbal and Western medicines, improved overall health of the host, and have exerted positive impact on the growth of gut dwelling beneficial bacteria. Specifically, the review is discussing the mechanism through which bacterial polysaccharides exert anti-inflammatory, antioxidant, anti-cancer, and anti-microbial properties. In addition, they are holding promising application in the 3D printing. The review is also discussing a perspective about the metagenome-based screening of polysaccharides, their integration with other cutting-edge tools, and synthetic microbiome base intervention of polysaccharides as a strategy for prebiotic intervention. This review has collected interesting information about the bacterial polysaccharides from Google Scholar, PubMed, Scopus, and Web of Science databases. Up to our knowledge, this is the first of its kind review article that is summarizing therapeutic, prebiotics, and commercial application of bacterial polysaccharides.
细菌多糖因其更高的纯度、亲水性以及精细的三维纤维结构而独具特色。这些聚合物主要为微生物提供保护、支撑和能量，然而，最近这些生物聚合物的一些辅助特性已被揭示。微生物多糖已显示出针对各种疾病的治疗能力，增强了草药和西药的治愈能力，改善了宿主的整体健康状况，并对肠道有益细菌的生长产生了积极影响。具体而言，本综述正在探讨细菌多糖发挥抗炎、抗氧化、抗癌和抗菌特性的机制。此外，它们在3D打印方面具有广阔的应用前景。本综述还讨论了基于宏基因组筛选多糖的前景、它们与其他前沿工具的整合，以及将多糖的合成微生物群干预作为益生元干预策略的相关内容。本综述从谷歌学术、PubMed、Scopus和科学网数据库中收集了有关细菌多糖的有趣信息。据我们所知，这是第一篇总结细菌多糖治疗、益生元及商业应用的综述文章。
