Kong Fanhui, Mehwish Nabila, Lee Bae Hoon
School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, 510006, China.
Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China.
Acta Biomater. 2023 Feb;157:67-90. doi: 10.1016/j.actbio.2022.11.058. Epub 2022 Dec 9.
Developing biomaterials-based tissue engineering scaffolds with personalized features and intrinsic biocompatibility is appealing and urgent. Through utilizing various strategies, albumin, as the most abundant protein in plasma, could be fabricated into sustainable, cost-effective, and potentially personalized hydrogels that would display enormous biological applications. To date, much of the albumin-based research is primarily engrossed in using albumin as a therapeutic molecule or a drug carrier, not much as a scaffold for tissue engineering. For this reason, we have come up with a detailed and insightful review of recent progress in albumin-based hydrogels having an emphasis on production techniques, material characteristics, and biological uses. It is envisioned that albumin-based scaffolds would be appealing and useful platforms to meet current tissue engineering needs and achieve the goal of clinical translation to benefit patients. STATEMENT OF SIGNIFICANCE: The creation of autologous material-based scaffolds is a potential method for preventing immunological reactions and obtaining the best therapeutic results. Patient-derived albumin hydrogels may consequently provide improved opportunities for personalized treatment due to their abundant supply and minimal immunogenicity. To provide a detailed and insightful summary on albumin-based hydrogels, this review includes latest comprehensive information on their preparation procedures, features, and applications in 3D printing and other biomedical applications. The challenges, along with the future potential for implementing albumin-based hydrogels in clinics, have also been addressed.
开发具有个性化特征和内在生物相容性的生物材料基组织工程支架既具有吸引力又十分迫切。通过运用各种策略，白蛋白作为血浆中最丰富的蛋白质，可以被制成可持续、具有成本效益且可能实现个性化的水凝胶，展现出巨大的生物学应用潜力。到目前为止，许多基于白蛋白的研究主要集中在将白蛋白用作治疗分子或药物载体，而很少将其用作组织工程支架。因此，我们对基于白蛋白的水凝胶的最新进展进行了详细且有见地的综述，重点关注其生产技术、材料特性和生物学用途。可以预见，基于白蛋白的支架将是满足当前组织工程需求并实现临床转化以造福患者目标的有吸引力且实用的平台。重要性声明：创建基于自体材料的支架是预防免疫反应并获得最佳治疗效果的一种潜在方法。因此，患者来源的白蛋白水凝胶因其丰富的供应和最小的免疫原性，可能为个性化治疗提供更好的机会。为了对基于白蛋白的水凝胶进行详细且有见地的总结，本综述包括了有关其制备过程、特性以及在3D打印和其他生物医学应用中的最新全面信息。还探讨了在临床中应用基于白蛋白的水凝胶所面临的挑战以及未来的潜力。
