文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

银纳米颗粒的环保制备及其对肺癌的抗增殖和诱导凋亡能力

Eco-Friendly Preparation of Silver Nanoparticles and Their Antiproliferative and Apoptosis-Inducing Ability against Lung Cancer.

作者信息

Suseela Vivekananthan, Nirmaladevi Ramalingam, Pallikondaperumal Muthukrishnan, Priya Ramasamy Shanmuga, Shaik Mohammed Rafi, Shaik Althaf Hussain, Khan Mujeeb, Shaik Baji

机构信息

Department of Biochemistry, P.S.G College of Arts and Science, Coimbatore 641014, Tamilnadu, India.

Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641043, Tamilnadu, India.

出版信息

Life (Basel). 2022 Dec 15;12(12):2123. doi: 10.3390/life12122123.

DOI:10.3390/life12122123
PMID:36556488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9782107/
Abstract

In the present study, the anti-proliferative and apoptotic potential of in lung cancer was assessed. Silver nanoparticles (AgNPs) of were synthesized using an ethanolic extract and characterized by adopting various parameters. Herein, the eco-friendly, cost-effective, and green synthesis of AgNPs was evaluated using an ethanolic extract of . The as-synthesized AgNPs were then characterized using various characterization techniques, such as UV-visible spectroscopy (UV-vis), X-ray powder diffraction (XRD), dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The AgNPs are crystalline, spherical, and highly stable AgNPs of varying sizes in the range of 5-20 nm. The anticancer activity of the ethanolic extract of and its AgNPs was determined using an MTT assay. The results indicated that, although both samples showed prominent anti-proliferative activity on lung cancer cell lines, the AgNPs of were found to be more potent than the ethanolic extract. Further, apoptosis induction ability was evaluated by FITC Annexin V and PI staining, the results of which demonstrated the efficiency of the ethanolic extract of and its AgNPs in causing oxidative stress and subsequent cellular death. This was subsequently further confirmed by measuring the mitochondrial membrane potential after staining the cells with JC1. The apoptotic mode of cell death was further confirmed by DNA fragmentation and caspase assays using Western blot analysis.

摘要

在本研究中，评估了[提取物名称]在肺癌中的抗增殖和凋亡潜力。使用乙醇提取物合成了[提取物名称]的银纳米颗粒（AgNPs），并采用各种参数对其进行了表征。在此，使用[提取物名称]的乙醇提取物评估了AgNPs的生态友好、成本效益高的绿色合成方法。然后，使用各种表征技术对合成的AgNPs进行表征，如紫外可见光谱（UV-vis）、X射线粉末衍射（XRD）、动态光散射（DLS）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）。AgNPs是结晶的、球形的，并且是尺寸在5-20nm范围内变化的高度稳定的AgNPs。使用MTT测定法测定了[提取物名称]的乙醇提取物及其AgNPs的抗癌活性。结果表明，尽管两个样品在肺癌细胞系上均显示出显著的抗增殖活性，但发现[提取物名称]的AgNPs比乙醇提取物更有效。此外，通过FITC膜联蛋白V和PI染色评估了凋亡诱导能力，其结果证明了[提取物名称]的乙醇提取物及其AgNPs在引起氧化应激和随后的细胞死亡方面的效率。在用JC1对细胞进行染色后，通过测量线粒体膜电位进一步证实了这一点。通过使用蛋白质免疫印迹分析的DNA片段化和半胱天冬酶测定进一步证实了细胞死亡的凋亡模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/14b4a211e59e/life-12-02123-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/e5313fd07538/life-12-02123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/994e868c6550/life-12-02123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/6128d8d9029f/life-12-02123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/0fcce8a87213/life-12-02123-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/05e45f559b0a/life-12-02123-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/65095800f8f4/life-12-02123-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/cbda7be9c3ca/life-12-02123-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/e8428e09b3d9/life-12-02123-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/92ec2c0170d9/life-12-02123-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/d8d36e8e6cc6/life-12-02123-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/0c88e65dbd80/life-12-02123-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/4274cbc14415/life-12-02123-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/a40915f8906d/life-12-02123-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/288bf7cf2b5f/life-12-02123-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/2d7bb3aa9659/life-12-02123-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/14b4a211e59e/life-12-02123-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/e5313fd07538/life-12-02123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/994e868c6550/life-12-02123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/6128d8d9029f/life-12-02123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/0fcce8a87213/life-12-02123-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/05e45f559b0a/life-12-02123-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/65095800f8f4/life-12-02123-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/cbda7be9c3ca/life-12-02123-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/e8428e09b3d9/life-12-02123-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/92ec2c0170d9/life-12-02123-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/d8d36e8e6cc6/life-12-02123-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/0c88e65dbd80/life-12-02123-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/4274cbc14415/life-12-02123-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/a40915f8906d/life-12-02123-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/288bf7cf2b5f/life-12-02123-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/2d7bb3aa9659/life-12-02123-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/647a/9782107/14b4a211e59e/life-12-02123-g016.jpg

相似文献

[1]
Eco-Friendly Preparation of Silver Nanoparticles and Their Antiproliferative and Apoptosis-Inducing Ability against Lung Cancer.

Life (Basel). 2022-12-15

[2]
-Mediated Green Synthesis of Silver Nanoparticles Exhibits Antimicrobial Effect and Anti-Oncogenic Activity against Glioblastoma U118 MG Cancer Cell Line.

Nanomaterials (Basel). 2022-1-30

[3]
Effect of operational parameters, characterization and antibacterial studies of green synthesis of silver nanoparticles using .

PeerJ. 2018-10-30

[4]
Green synthesis of silver nanoparticles using extract of oak fruit hull (jaft): synthesis and in vitro cytotoxic effect on mcf-7 cells.

Int J Breast Cancer. 2015

[5]
Eco-Friendly and Facile Synthesis of Antioxidant, Antibacterial and Anticancer Dihydromyricetin-Mediated Silver Nanoparticles.

Int J Nanomedicine. 2021

[6]
Synthesis and characterization of biogenic metal nanoparticles and its cytotoxicity and anti-neoplasticity through the induction of oxidative stress, mitochondrial dysfunction and apoptosis.

Colloids Surf B Biointerfaces. 2017-10-13

[7]
Eco-friendly green synthesis of silver nanoparticles and their potential applications as antioxidant and anticancer agents.

Drug Dev Ind Pharm. 2019-9-2

[8]
Green synthesis of silver nanoparticles using Andean blackberry fruit extract.

Saudi J Biol Sci. 2017-1

[9]
Apoptosis induction in lung and prostate cancer cells through silver nanoparticles synthesized from Pinus roxburghii bioactive fraction.

J Biol Inorg Chem. 2020-2

[10]
Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy.

Int J Nanomedicine. 2015-6-29

引用本文的文献

[1]
In Vitro Antiproliferative Activity in Plants of the Genus : A Systematic Review.

Molecules. 2025-5-25

[2]
Bioactive Molecules of Microalgae -Mediated Synthesized Silver Nanoparticles: Antioxidant, Antimicrobial, Antibiofilm, Hemolysis Assay, and Anticancer.

Bioinorg Chem Appl. 2025-5-2

[3]
Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer.

Hereditas. 2025-4-17

[4]
Nanoparticle trends and hotspots in lung cancer diagnosis from 2006-2023: a bibliometric analysis.

Front Oncol. 2024-12-20

[5]
Biosynthesis of Copper Oxide-Silver Nanoparticles from Ephedra Intermedia Extract and Study of Anticancer Effects in HepG2 Cell Line: Apoptosis-Related Genes Analysis and Nitric Oxide Level Investigations.

Int J Mol Cell Med. 2024

[6]
Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis.

Biomed Res Int. 2024

[7]
All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction.

APL Bioeng. 2023-9-13

[8]
The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Life (Basel). 2023-2-7

[9]
Activities against Lung Cancer of Biosynthesized Silver Nanoparticles: A Review.

Biomedicines. 2023-1-28

本文引用的文献

[1]
Antimicrobial, Antiviral, and In-Vitro Cytotoxicity and Mosquitocidal Activities of -Based Green Synthesis of Selenium Nanoparticles.

J Funct Biomater. 2022-9-19

[2]
Combination Effect of Novel Bimetallic Ag-Ni Nanoparticles with Fluconazole against .

J Fungi (Basel). 2022-7-14

[3]
Polyphenol-Capped Biogenic Synthesis of Noble Metallic Silver Nanoparticles for Antifungal Activity against .

J Fungi (Basel). 2022-6-16

[4]
Mycosynthesis, Characterization, and Mosquitocidal Activity of Silver Nanoparticles Fabricated by Strain.

J Fungi (Basel). 2022-4-13

[5]
Enhanced Antimicrobial, Cytotoxicity, Larvicidal, and Repellence Activities of Brown Algae, -Mediated Green Synthesis of Magnesium Oxide Nanoparticles.

Front Bioeng Biotechnol. 2022-2-28

[6]
Assisted Fabrication of Novel Ag-Cu Bimetallic Nanoparticles for Growth Inhibition and Virulence in .

Pharmaceutics. 2021-11-18

[7]
Green Synthesis of Zinc Oxide Nanoparticles (ZnO-NPs) by and Their Activity against Pathogenic Microbes and Common House Mosquito, .

Materials (Basel). 2021-11-18

[8]
L.-Mediated Green Synthesis of Silver Nanoparticles Exhibiting Antioxidant and Anticancer Activities.

Nanomaterials (Basel). 2021-2-14

[9]
Antimicrobial and In Vitro Cytotoxic Efficacy of Biogenic Silver Nanoparticles (Ag-NPs) Fabricated by Callus Extract of L.

Biomolecules. 2021-2-24

[10]
Green Synthesis of Silver Nanoparticles Using Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy.

Nanomaterials (Basel). 2021-2-3

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索