Liu Xiaojin, Yang Luodan, Li Guangyao, Jiang Yingnan, Zhang Guoying, Ling Jianya
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Department of Pharmacy, Shandong Medical College, Linyi 276000, China.
College of Physical Education and Sports Science, South China Normal University, Guangzhou 510006, China.
Int J Biol Macromol. 2023 Feb 28;229:168-180. doi: 10.1016/j.ijbiomac.2022.12.276. Epub 2022 Dec 29.
Nervous system diseases (NSDs) are characterized by a wide range of symptoms, a complex pathophysiology, an unclear etiology, a great deal of variation in treatment response, and lengthy therapy cycles, all of which pose considerable hurdles to clinical treatment. A traditional valuable medicine known as Ganoderma lucidum (GL) has a significant role to play in preserving health and treating diseases. Ganoderma lucidum polysaccharides (GLP) is one of the cardinal effective active ingredients of GL, which has a number of pharmacological actions, including liver protection, immune regulation, antioxidant activity, anticancer activity, antibacterial activity, and antiviral activity. Recently, studies on the structural characterization and biological functions of GLP were presented in this article to review the progress of researches about GLP on NSDs and summarize the potential mechanisms of action. These studies were anticipated to provide new research ideas for GLP as a novel promising neuroprotective agent and provide a reference for better development and utilization of GLP.
神经系统疾病（NSDs）具有症状多样、病理生理复杂、病因不明、治疗反应差异大以及治疗周期长等特点，所有这些都给临床治疗带来了相当大的障碍。一种传统的珍贵药物灵芝（GL）在保健和治疗疾病方面具有重要作用。灵芝多糖（GLP）是GL的主要有效活性成分之一，具有多种药理作用，包括肝脏保护、免疫调节、抗氧化活性、抗癌活性、抗菌活性和抗病毒活性。本文介绍了近年来关于GLP结构表征和生物学功能的研究，以综述GLP对NSDs的研究进展，并总结其潜在作用机制。这些研究有望为GLP作为一种新型有前景的神经保护剂提供新的研究思路，并为GLP的更好开发和利用提供参考。
