发酵乳制品的消费与抑郁症状：队列研究的荟萃分析。
Fermented dairy foods consumption and depressive symptoms: A meta-analysis of cohort studies.
机构信息
West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, People's Republic of China.
出版信息
PLoS One. 2023 Feb 6;18(2):e0281346. doi: 10.1371/journal.pone.0281346. eCollection 2023.
BACKGROUND
The gut-brain axis has been potentially proposed as a link between the intake of fermented dairy foods and depression. We carried out this meta-analysis on published cohort studies to estimate the overall depression risk of fermented dairy foods intake.
METHODS
We searched the CNKI (China National Knowledge Infrastructure) and PubMed databases for all articles within a range of published years from 2010 to 2022 on the association between fermented dairy foods intake and depression.
RESULTS
Finally, 8 studies met the inclusion criteria for this study, with 83,533 participants. Overall, there was statistical evidence of significantly decreased depression risk was found to be associated with fermented dairy foods intake (OR = 0.89, 95% CI = 0.81-0.98). In subgroup analysis, cheese and yogurt consumptions were significantly associated with decreased depression risk (OR = 0.91, 95% CI = 0.84-0.98 for cheese and OR = 0. 84, 95% CI = 0.72-0.99 for yogurt). However, we failed to find superabundant intake of fermented dairy foods intake decreased the risk of depression.
CONCLUSION
Our meta-analysis indicated that fermented dairy foods intake may have potential beneficial effect on depression via the gut-brain axis.
背景
肠道-大脑轴被认为是发酵乳制品摄入与抑郁症之间的联系。我们进行了这项荟萃分析，以评估发酵乳制品摄入与抑郁症之间的总体风险。
方法
我们检索了中国知网（CNKI）和 PubMed 数据库，以获取 2010 年至 2022 年发表的关于发酵乳制品摄入与抑郁症之间关联的所有文章。
结果
最终，有 8 项研究符合纳入标准，共 83533 名参与者。总体而言，有统计学证据表明，发酵乳制品摄入与降低抑郁症风险显著相关（OR = 0.89，95%CI = 0.81-0.98）。在亚组分析中，奶酪和酸奶的摄入与降低抑郁症风险显著相关（奶酪 OR = 0.91，95%CI = 0.84-0.98；酸奶 OR = 0.84，95%CI = 0.72-0.99）。然而，我们未能发现大量摄入发酵乳制品可以降低抑郁症的风险。
结论
我们的荟萃分析表明，发酵乳制品摄入可能通过肠道-大脑轴对抑郁症产生潜在的有益影响。
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