Lai Yifan, Wang Jingyu, Yue Ning, Zhang Qiaochu, Wu Jiangjiexing, Qi Wei, Su Rongxin
State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P.R. China.
Zhejiang Institute of Tianjin University, Ningbo, Zhejiang 315201, P.R. China.
Biomater Sci. 2023 Mar 28;11(7):2292-2316. doi: 10.1039/d2bm01915a.
The field of nanozymes is developing rapidly. In particular, glutathione peroxidase (GPx)-like nanozymes, which catalytically reduce HO/organic hydroperoxides to HO/alcohols, have attracted considerable attention. GPx-like nanozymes are powerful antioxidant enzymes known to combat oxidative stress. They have broad applications, including cytoprotection, anti-inflammation, neuroprotection, tumor therapy, and anti-aging. Although much progress has been made, GPx-like nanozymes have not been well discussed or fully reviewed as other nanozymes. This review aims to summarize recent advances on GPx-like nanozymes from the vantage point of mechanism, classification, and bioapplication. Future prospects for advancing their design and application are also discussed.
纳米酶领域正在迅速发展。特别是，具有谷胱甘肽过氧化物酶（GPx）活性的纳米酶，能够催化将过氧化氢/有机过氧化物还原为水/醇，已引起了相当大的关注。具有GPx活性的纳米酶是强大的抗氧化酶，已知可对抗氧化应激。它们具有广泛的应用，包括细胞保护、抗炎、神经保护、肿瘤治疗和抗衰老。尽管已经取得了很大进展，但与其他纳米酶相比，具有GPx活性的纳米酶尚未得到充分讨论或全面综述。本综述旨在从作用机制、分类和生物应用的角度总结具有GPx活性的纳米酶的最新进展。还讨论了推进其设计和应用的未来前景。
