Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Regensburg, 93040, Germany.
Mikrochim Acta. 2023 Feb 15;190(3):91. doi: 10.1007/s00604-023-05666-6.
Silver nanoparticles (AgNPs) have long been overshadowed by gold NPs' success in sensor and point-of-care (POC) applications. However, their unique physical, (electro)chemical, and optical properties make them excellently suited for such use, as long as their inherent higher instability toward oxidation is controlled. Recent advances in this field provide novel strategies that demonstrate that the AgNPs' inherent capabilities improve sensor performance and enable the specific detection of analytes at low concentrations. We provide an overview of these advances by focusing on the nanosized Ag (in the range of 1-100 nm) properties with emphasis on optical and electrochemical biosensors. Furthermore, we critically assess their potential for point-of-care sensors discussing advantages as well as limitations for each detection technique. We can conclude that, indeed, strategies using AgNP are ready for sensitive POC applications; however, research focusing on the simplification of assay procedures is direly needed for AgNPs to make the successful jump into actual applications.
银纳米粒子（AgNPs）在传感器和即时检测（POC）应用中一直被金纳米粒子（AuNPs）的成功所掩盖。然而，只要控制其内在的更高氧化不稳定性，它们独特的物理、（电）化学和光学特性使它们非常适合此类用途。该领域的最新进展提供了新的策略，证明了 AgNPs 的固有能力可以提高传感器的性能，并能够在低浓度下特异性地检测分析物。我们通过重点关注纳米级 Ag（尺寸在 1-100nm 范围内）的光学和电化学生物传感器的特性，概述了这些进展。此外，我们还批判性地评估了它们在即时检测传感器中的应用潜力，讨论了每种检测技术的优势和局限性。我们可以得出结论，确实，使用 AgNP 的策略已经为敏感的 POC 应用做好了准备；然而，迫切需要研究简化检测程序，使 AgNPs 能够成功地应用于实际应用。
