Yu Xiaoyun, Shi Yongmei, Yuan Rongtao, Chen Zhenggang, Dong Quanjiang, Han Linzi, Wang Lili, Zhou Jianhua
Graduate School of Dalian Medical University, Dalian, 116044, China.
Department of Stomatology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Heliyon. 2023 Jan 24;9(2):e13198. doi: 10.1016/j.heliyon.2023.e13198. eCollection 2023 Feb.
The aim of this study was to summarize previously published data and assess the alterations in the composition of the oral microbiome in OSCC using a systematic review and meta-analysis.
Electronic databases were systematically searched for studies on the oral microbiome in OSCC published before December 2021. Qualitative assessments of compositional variations at the phylum level were performed. The meta-analysis on abundance changes of bacteria genera was performed via a random-effects model.
A total of 18 studies involving 1056 participants were included. They consisted of two categories of studies: 1) case-control studies (n = 9); 2) nine studies that compared the oral microbiome between cancerous tissues and paired paracancerous tissues. At the phylum level, enrichment of Fusobacteria but depletion in Actinobacteria and Firmicutes in the oral microbiome was demonstrated in both categories of studies. At the genus level, showed an increased abundance in OSCC patients (SMD = 0.65, 95% CI: 0.43-0.87, Z = 5.809, = 0.000) and in cancerous tissues (SMD = 0.54, 95% CI: 0.36-0.72, Z = 5.785, = 0.000). The abundance of was decreased in OSCC (SMD = -0.46, 95% CI: -0.88-0.04, Z = -2.146, = 0.032) and in cancerous tissues (SMD = -0.45, 95% CI: -0.78-0.13, Z = -2.726, = 0.006).
Disturbances in the interactions between enriched and depleted may participate in or prompt the occurrence and development of OSCC and could be potential biomarkers for detection of OSCC.
本研究旨在汇总先前发表的数据，并通过系统评价和荟萃分析评估口腔鳞状细胞癌（OSCC）中口腔微生物群组成的变化。
对电子数据库进行系统检索，以查找2021年12月之前发表的关于OSCC中口腔微生物群的研究。对门水平的组成变化进行定性评估。通过随机效应模型对细菌属丰度变化进行荟萃分析。
共纳入18项研究，涉及1056名参与者。这些研究包括两类：1）病例对照研究（n = 9）；2）9项比较癌组织和配对癌旁组织口腔微生物群的研究。在门水平上，两类研究均显示口腔微生物群中梭杆菌富集，但放线菌和厚壁菌减少。在属水平上，[具体菌属未给出]在OSCC患者中丰度增加（标准化均数差（SMD）= 0.65，95%可信区间（CI）：0.43 - 0.87，Z = 5.809，P = 0.000），在癌组织中也增加（SMD = 0.54，95% CI：0.36 - 0.72，Z = 5.785，P = 0.000）。[另一具体菌属未给出]在OSCC中丰度降低（SMD = -0.46，95% CI：-0.88 - 0.04，Z = -2.146，P = 0.032），在癌组织中也降低（SMD = -0.45，95% CI：-0.78 - 0.13，Z = -2.726，P = 0.006）。
富集的[具体菌属未给出]和减少的[具体菌属未给出]之间相互作用的紊乱可能参与或促使OSCC发生发展，并且可能是检测OSCC的潜在生物标志物。
