南极海绵源真菌 HDN151418 衍生的抗菌环三肽。
Antibacterial Cyclic Tripeptides from Antarctica-Sponge-Derived Fungus HDN151418.
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China.
出版信息
Mar Drugs. 2020 Oct 26;18(11):532. doi: 10.3390/md18110532.
Three new aspochracin-type cyclic tripeptides, sclerotiotides M-O (-), together with three known analogues, sclerotiotide L (), sclerotiotide F (), and sclerotiotide B (), were obtained from the ethyl acetate extract of the fungus HDN151418, which was isolated from an unidentified Antarctica sponge. Spectroscopic and chemical approaches were used to elucidate their structures. The absolute configuration of the side chain in compound was elucidated for the first time. Compounds and showed broad antimicrobial activity against a panel of pathogenic strains, including , , , , , , MRCNS, and MRSA, with MIC values ranging from 1.56 to 25.0 µM.
三种新的 Asperchracin 型环三肽，即 sclerotiotides M-O (-)，与三种已知类似物，sclerotiotide L (), sclerotiotide F (), 和 sclerotiotide B (), 从真菌 HDN151418 的乙酸乙酯提取物中获得，该真菌是从一种未鉴定的南极洲海绵中分离出来的。采用光谱和化学方法阐明了它们的结构。首次阐明了化合物中侧链的绝对构型。化合物 和 对包括 、 、 、 、 、MRCNS 和 MRSA 在内的一系列病原菌具有广泛的抗菌活性，MIC 值范围为 1.56 至 25.0 μM。
Zotero 插件