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鳄鱼油对大鼠认知功能的抗氧化活性

Antioxidant Activity of Crocodile Oil () on Cognitive Function in Rats.

作者信息

Srisuksai Krittika, Parunyakul Kongphop, Santativongchai Pitchaya, Phaonakrop Narumon, Roytrakul Sittiruk, Tulayakul Phitsanu, Fungfuang Wirasak

机构信息

Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.

Bio-Veterinary Science (International Program), Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

出版信息

Foods. 2023 Feb 13;12(4):791. doi: 10.3390/foods12040791.

DOI:10.3390/foods12040791
PMID:36832865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9956878/
Abstract

Crocodile oil (CO) is rich in monounsaturated fatty acids and polyunsaturated fatty acids. The antioxidant activity and cognitive effect of monounsaturated fatty acids and polyunsaturated fatty acids have been largely reported. This work aimed to investigate the effect of CO on antioxidant activity and cognitive function in rats. Twenty-one rats were divided into three treatment groups: (1) sterile water (NS), (2) 1 mL/kg of CO (NC1), and (3) 3 mL/kg of CO (NC3). Rats underwent oral gavage once daily for 8 weeks. CO treatment decreased the triglycerides level significantly compared with that in the NS group. CO had a free radical scavenging ability greater than that of olive oil but had no effect on levels of antioxidant markers in the brain. Expression of unique proteins in the CO-treatment group were correlated with the detoxification of hydrogen peroxide. Rats in the NC1 group had better memory function than rats in the NC3 group. Expression of unique proteins in the NC1 group was correlated with memory function. However, CO did not cause a decline in cognitive function in rats. CO can be an alternative dietary oil because it has a hypolipidemia effect and antioxidant activity. In addition, CO did not cause a negative effect on cognitive function.

摘要

鳄鱼油（CO）富含单不饱和脂肪酸和多不饱和脂肪酸。单不饱和脂肪酸和多不饱和脂肪酸的抗氧化活性及认知作用已有大量报道。本研究旨在探究鳄鱼油对大鼠抗氧化活性及认知功能的影响。将21只大鼠分为三个处理组：（1）无菌水（NS）组，（2）1 mL/kg鳄鱼油（NC1）组，（3）3 mL/kg鳄鱼油（NC3）组。大鼠每天经口灌胃一次，持续8周。与NS组相比，鳄鱼油处理显著降低了甘油三酯水平。鳄鱼油的自由基清除能力强于橄榄油，但对大脑中抗氧化标志物水平无影响。鳄鱼油处理组中独特蛋白质的表达与过氧化氢的解毒作用相关。NC1组大鼠的记忆功能优于NC3组大鼠。NC1组中独特蛋白质的表达与记忆功能相关。然而，鳄鱼油并未导致大鼠认知功能下降。鳄鱼油可作为一种替代食用油，因为它具有降血脂作用和抗氧化活性。此外，鳄鱼油对认知功能无负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/e90619c16993/foods-12-00791-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/3da875537912/foods-12-00791-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/998f0c7d89eb/foods-12-00791-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/48fda5613636/foods-12-00791-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/b391dda2aa2d/foods-12-00791-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/3def8ad16037/foods-12-00791-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/e90619c16993/foods-12-00791-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/3da875537912/foods-12-00791-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/998f0c7d89eb/foods-12-00791-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/48fda5613636/foods-12-00791-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/b391dda2aa2d/foods-12-00791-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/3def8ad16037/foods-12-00791-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68dc/9956878/e90619c16993/foods-12-00791-g006.jpg

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