超越生物膜风险：细菌生存与潜在抗生物膜药物的新兴战场

Zeineldin Mohamed, Esmael Ahmed, Al-Hindi Rashad R, Alharbi Mona G, Ashenafi Bekele Debebe, Teklemariam Addisu D

Department of Animal Medicine, College of Veterinary Medicine, Benha University, Benha 13511, Egypt.

Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, NE 68583, USA.

Life (Basel). 2023 Feb 11;13(2):503. doi: 10.3390/life13020503.

Microbial pathogens and their virulence factors like biofilms are one of the major factors which influence the disease process and its outcomes. Biofilms are a complex microbial network that is produced by bacteria on any devices and/or biotic surfaces to escape harsh environmental conditions and antimicrobial effects. Due to the natural protective nature of biofilms and the associated multidrug resistance issues, researchers evaluated several natural anti-biofilm agents, including bacteriophages and their derivatives, honey, plant extracts, and surfactants for better destruction of biofilm and planktonic cells. This review discusses some of these natural agents that are being put into practice to prevent biofilm formation. In addition, we highlight bacterial biofilm formation and the mechanism of resistance to antibiotics.

微生物病原体及其生物膜等毒力因子是影响疾病进程及其结果的主要因素之一。生物膜是一种复杂的微生物网络，由细菌在任何器械和/或生物表面产生，以逃避恶劣的环境条件和抗菌作用。由于生物膜的天然保护特性以及相关的多重耐药性问题，研究人员评估了几种天然抗生物膜剂，包括噬菌体及其衍生物、蜂蜜、植物提取物和表面活性剂，以期更好地破坏生物膜和浮游细胞。本综述讨论了一些正在实际应用中用于预防生物膜形成的天然制剂。此外，我们还重点介绍了细菌生物膜的形成以及对抗生素的耐药机制。