de Andrade Gandolfi Flora, Estofolete Cassia Fernanda, Wakai Marcia Catelan, Negri Andreia Francesli, Barcelos Michela Dias, Vasilakis Nikos, Nogueira Mauricio Lacerda
Laboratório de Pesquisas em Virologia (LPV), Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
Hospital da Criança e Maternidade de São José do Rio Preto, São José do Rio Preto 15091-240, SP, Brazil.
Vaccines (Basel). 2023 Feb 15;11(2):445. doi: 10.3390/vaccines11020445.
The disease burden of yellow fever virus infection (YFV) is quite high in the tropics where vaccination coverage is low. To date, vaccination is the most effective control strategy to mitigate and eliminate the burden of YF disease. The licensed YF vaccines are safe and effective and serious adverse events are rare. Herein, we report three cases of neurological syndrome, compatible with meningoencephalitis following 17DD vaccination. In all cases, YFV-specific IgM antibodies were detected in the cerebrospinal fluid. Our observations confirm the development of YF vaccine-associated neurotropic disease, a rare serious adverse event, from which all three patients have fully recovered without any long-term sequelae. This report reinforces the need for awareness among health professionals to recognize and effectively manage such events in a timely manner.
在热带地区，黄热病病毒感染（YFV）的疾病负担相当高，而这些地区的疫苗接种覆盖率较低。迄今为止，接种疫苗是减轻和消除黄热病（YF）疾病负担的最有效控制策略。已获许可的黄热病疫苗安全有效，严重不良事件罕见。在此，我们报告3例接种17DD疫苗后出现的与脑膜脑炎相符的神经综合征病例。在所有病例中，脑脊液中均检测到YFV特异性IgM抗体。我们的观察结果证实了黄热病疫苗相关神经嗜性疾病的发生，这是一种罕见的严重不良事件，所有3例患者均已完全康复，无任何长期后遗症。本报告强化了卫生专业人员提高认识，以便及时识别并有效处理此类事件的必要性。
