Key Laboratory of Forest Plant Ecology, Ministry of Education, College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, China.
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Adv Healthc Mater. 2023 Aug;12(20):e2300153. doi: 10.1002/adhm.202300153. Epub 2023 Apr 9.
The tumor microenvironment (TME) is a complex and variable region characterized by hypoxia, low pH, high redox status, overexpression of enzymes, and high-adenosine triphosphate concentrations. In recent years, with the continuous in-depth study of nanomaterials, more and more TME-specific response nanomaterials are used for tumor treatment. However, the complexity of the TME causes different types of responses with various strategies and mechanisms of action. Aiming to systematically demonstrate the recent advances in research on TME-responsive nanomaterials, this work summarizes the characteristics of TME and outlines the strategies of different TME responses. Representative reaction types are illustrated and their merits and demerits are analyzed. Finally, forward-looking views on TME-response strategies for nanomaterials are presented. It is envisaged that such emerging strategies for the treatment of cancer are expected to exhibit dramatic trans-clinical capabilities, demonstrating the extensive potential for the diagnosis and therapy of cancer.
肿瘤微环境（TME）是一个复杂且多变的区域，其特点是缺氧、低 pH 值、高氧化还原状态、酶的过度表达和高三磷酸腺苷浓度。近年来，随着纳米材料的不断深入研究，越来越多的 TME 特异性反应纳米材料被用于肿瘤治疗。然而，TME 的复杂性导致不同类型的反应具有不同的策略和作用机制。本工作旨在系统地展示 TME 响应纳米材料的最新研究进展，总结 TME 的特征，并概述不同 TME 反应的策略。代表性的反应类型被举例说明，并分析了它们的优缺点。最后，对 TME 响应纳米材料的策略提出了前瞻性的看法。预计这些新兴的癌症治疗策略将表现出显著的临床转化能力，为癌症的诊断和治疗展示出广泛的潜力。
