Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Chengdu, China.
Department of Orthopedics, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Chengdu, China.
Front Endocrinol (Lausanne). 2023 Mar 16;14:1134318. doi: 10.3389/fendo.2023.1134318. eCollection 2023.
A large body of literature has demonstrated the significant efficacy of antibiotic bone cement in treating infected diabetic foot wounds, but there is less corresponding evidence-based medical evidence. Therefore, this article provides a meta-analysis of the effectiveness of antibiotic bone cement in treating infected diabetic foot wounds to provide a reference basis for clinical treatment.
PubMed, Embase, Cochrane library, Scoup, China Knowledge Network (CNKI), Wanfang database, and the ClinicalTrials.gov were searched, and the search time was from the establishment of the database to October 2022, and two investigators independently. Two investigators independently screened eligible studies, evaluated the quality of the literature using the Cochrane Evaluation Manual, and performed statistical analysis of the data using RevMan 5.3 software.
A total of nine randomized controlled studies (n=532) were included and, compared with the control group, antibiotic bone cement treatment reduced the time to wound healing (MD=-7.30 95% CI [-10.38, -4.23]), length of hospital stay (MD=-6.32, 95% CI [-10.15, -2.48]), time to bacterial conversion of the wound (MD=-5.15, 95% CI [-7.15,-2.19]), and the number of procedures (MD=-2.35, 95% CI [-3.68, -1.02]).
Antibiotic bone cement has significant advantages over traditional treatment of diabetic foot wound infection and is worthy of clinical promotion and application.
PROSPERO identifier, CDR 362293.
大量文献证明抗生素骨水泥在治疗感染性糖尿病足创面方面具有显著疗效，但相应的循证医学证据较少。因此，本文对抗生素骨水泥治疗感染性糖尿病足创面的疗效进行了荟萃分析，为临床治疗提供参考依据。
检索PubMed、Embase、Cochrane 图书馆、Scoup、中国知网（CNKI）、万方数据库和 ClinicalTrials.gov，检索时间为建库至 2022 年 10 月，由 2 名研究者独立筛选合格研究，使用 Cochrane 评价手册评价文献质量，并使用 RevMan 5.3 软件进行数据分析。
共纳入 9 项随机对照研究（n=532），与对照组相比，抗生素骨水泥治疗可缩短创面愈合时间（MD=-7.30，95%CI[-10.38，-4.23]）、住院时间（MD=-6.32，95%CI[-10.15，-2.48]）、创面细菌转化时间（MD=-5.15，95%CI[-7.15，-2.19]）和治疗次数（MD=-2.35，95%CI[-3.68，-1.02]）。
抗生素骨水泥在治疗糖尿病足创面感染方面具有显著优势，值得临床推广应用。
PROSPERO 标识符，CDR 362293。
