Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL-MMD), School of Materials Science and Engineering, Peking University, Beijing 100871, China.
Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, Peking University, Beijing 100871, China.
J Am Chem Soc. 2023 May 24;145(20):11019-11032. doi: 10.1021/jacs.2c12219. Epub 2023 May 16.
Biomedical micro/nanorobots as active delivery systems with the features of self-propulsion and controllable navigation have made tremendous progress in disease therapy and diagnosis, detection, and biodetoxification. However, existing micro/nanorobots are still suffering from complex drug loading, physiological drug stability, and uncontrollable drug release. To solve these problems, micro/nanorobots and nanocatalytic medicine as two independent research fields were integrated in this study to achieve self-propulsion-induced deeper tumor penetration and catalytic reaction-initiated tumor therapy in vivo. We presented self-propelled Janus nanocatalytic robots (JNCRs) guided by magnetic resonance imaging (MRI) for in vivo enhanced tumor therapy. These JNCRs exhibited active movement in HO solution, and their migration in the tumor tissue could be tracked by non-invasive MRI in real time. Both increased temperature and reactive oxygen species production were induced by near-infrared light irradiation and iron-mediated Fenton reaction, showing great potential for tumor photothermal and chemodynamic therapy. In comparison with passive nanoparticles, these self-propelled JNCRs enabled deeper tumor penetration and enhanced tumor therapy after intratumoral injection. Importantly, these robots with biocompatible components and byproducts exhibited biosecurity in the mouse model. It is expected that our work could promote the combination of micro/nanorobots and nanocatalytic medicine, resulting in improved tumor therapy and potential clinical transformations.
生物医学微/纳机器人作为具有自主推进和可控导航功能的主动输送系统，在疾病治疗和诊断、检测以及生物解毒方面取得了巨大进展。然而，现有的微/纳机器人仍然存在复杂的药物加载、生理药物稳定性和不可控的药物释放等问题。为了解决这些问题，本研究将微/纳机器人和纳米催化药物这两个独立的研究领域结合起来，以实现自主推进诱导的更深肿瘤穿透和催化反应引发的体内肿瘤治疗。我们提出了基于磁共振成像（MRI）引导的自主推进的 Janus 纳米催化机器人（JNCR），用于体内增强肿瘤治疗。这些 JNCR 在 HO 溶液中表现出主动运动，其在肿瘤组织中的迁移可以通过非侵入性的实时 MRI 进行跟踪。近红外光照射和铁介导的芬顿反应诱导了温度升高和活性氧物质的产生，显示出用于肿瘤光热和化学动力学治疗的巨大潜力。与被动纳米颗粒相比，这些自主推进的 JNCR 在肿瘤内注射后能够实现更深的肿瘤穿透和增强的肿瘤治疗。重要的是，这些具有生物相容性成分和副产物的机器人在小鼠模型中表现出生物安全性。预计我们的工作将促进微/纳机器人和纳米催化药物的结合，从而改善肿瘤治疗并具有潜在的临床转化前景。
