Tabassum Nazish, Singh Virendra, Chaturvedi Vivek K, Vamanu Emanuel, Singh Mohan P
Centre of Biotechnology, University of Allahabad, Prayagraj 211002, India.
Centre for Interdisciplinary Research in Basics Sciences, Jamia Millia Islamia, New Delhi 110025, India.
Pharmaceutics. 2023 Jun 14;15(6):1726. doi: 10.3390/pharmaceutics15061726.
The objective of this study was to investigate the rhombohedral-structured, flower-like iron oxide (FeO) nanoparticles that were produced using a cost-effective and environmentally friendly coprecipitation process. The structural and morphological characteristics of the synthesized FeO nanoparticles were analyzed using XRD, UV-Vis, FTIR, SEM, EDX, TEM, and HR-TEM techniques. Furthermore, the cytotoxic effects of FeO nanoparticles on MCF-7 and HEK-293 cells were evaluated using in vitro cell viability assays, while the antibacterial activity of the nanoparticles against Gram-positive and Gram-negative bacteria (, , and ) was also tested. The results of our study demonstrated the potential cytotoxic activity of FeO nanoparticles toward MCF-7 and HEK-293 cell lines. The antioxidant potential of FeO nanoparticles was evidenced by the 1,1-diphenyl-2-picrylhydrazine (DPPH) and nitric oxide (NO) free radical scavenging assays. In addition, we suggested that FeO nanoparticles could be used in various antibacterial applications to prevent the spread of different bacterial strains. Based on these findings, we concluded that FeO nanoparticles have great potential for use in pharmaceutical and biological applications. The effective biocatalytic activity of FeO nanoparticles recommends its use as one of the best drug treatments for future views against cancer cells, and it is, therefore, recommended for both in vitro and in vivo in the biomedical field.
本研究的目的是研究通过具有成本效益且环保的共沉淀法制备的菱面体结构的花状氧化铁（FeO）纳米颗粒。使用XRD、UV-Vis、FTIR、SEM、EDX、TEM和HR-TEM技术分析了合成的FeO纳米颗粒的结构和形态特征。此外，使用体外细胞活力测定法评估了FeO纳米颗粒对MCF-7和HEK-293细胞的细胞毒性作用，同时还测试了纳米颗粒对革兰氏阳性和革兰氏阴性细菌（、和）的抗菌活性。我们的研究结果证明了FeO纳米颗粒对MCF-7和HEK-293细胞系具有潜在的细胞毒性活性。通过1,1-二苯基-2-苦基肼（DPPH）和一氧化氮（NO）自由基清除试验证明了FeO纳米颗粒的抗氧化潜力。此外，我们建议FeO纳米颗粒可用于各种抗菌应用，以防止不同细菌菌株的传播。基于这些发现，我们得出结论，FeO纳米颗粒在制药和生物应用中具有巨大的潜力。FeO纳米颗粒有效的生物催化活性表明其可作为未来对抗癌细胞的最佳药物治疗方法之一，因此，在生物医学领域的体外和体内应用中均推荐使用。
