尿中环磷酰胺检测作为职业性接触环磷酰胺生物监测的一种方法。
Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide.
作者信息
Evelo C T, Bos R P, Peters J G, Henderson P T
出版信息
Int Arch Occup Environ Health. 1986;58(2):151-5. doi: 10.1007/BF00380766.
PMID:3744569
Abstract
Urine of twenty hospital workers was monitored for the excretion of the cytostatic drug cyclophosphamide using GC-MSD. The drug was found to be present above the detection limit of 0.5 microgram/24 h urine in five cases. A clear relationship between cyclophosphamide handling and the detectability of excretion existed. This method developed can be of use for biological monitoring studies directed toward the finding of exposure hazards.
摘要
利用气相色谱-质谱联用仪（GC-MSD）对20名医院工作人员的尿液进行监测，以检测细胞抑制药物环磷酰胺的排泄情况。结果发现，有5例尿液中环磷酰胺的含量高于0.5微克/24小时尿液的检测限。环磷酰胺的接触情况与排泄的可检测性之间存在明显的关系。所开发的这种方法可用于旨在发现接触危害的生物监测研究。
Zotero 插件