Similarity-Driven Fine-Tuning Methods for Regularization Parameter Optimization in PET Image Reconstruction.

We present an adaptive method for fine-tuning hyperparameters in edge-preserving regularization for PET image reconstruction. For edge-preserving regularization, in addition to the smoothing parameter that balances data fidelity and regularization, one or more control parameters are typically incorporated to adjust the sensitivity of edge preservation by modifying the shape of the penalty function. Although there have been efforts to develop automated methods for tuning the hyperparameters in regularized PET reconstruction, the majority of these methods primarily focus on the smoothing parameter. However, it is challenging to obtain high-quality images without appropriately selecting the control parameters that adjust the edge preservation sensitivity. In this work, we propose a method to precisely tune the hyperparameters, which are initially set with a fixed value for the entire image, either manually or using an automated approach. Our core strategy involves adaptively adjusting the control parameter at each pixel, taking into account the degree of patch similarities calculated from the previous iteration within the pixel's neighborhood that is being updated. This approach allows our new method to integrate with a wide range of existing parameter-tuning techniques for edge-preserving regularization. Experimental results demonstrate that our proposed method effectively enhances the overall reconstruction accuracy across multiple image quality metrics, including peak signal-to-noise ratio, structural similarity, visual information fidelity, mean absolute error, root-mean-square error, and mean percentage error.