Droz P O, Guillemin M P
J Occup Med. 1986 Aug;28(8):593-602. doi: 10.1097/00043764-198608000-00014.
Breath analysis has been proposed on numerous occasions for monitoring solvent exposure. Nevertheless, it is still rarely used routinely because of difficulties in the methodology itself (sampling and analysis) and lack of data concerning its relationship to exposure dose. The various methods available today are briefly reviewed, compared, and discussed. Emphasis is on the simultaneous use of CO2 as a respiratory index. Two methods using this approach are presented. The advantages and limitations of breath analysis for occupational exposure monitoring are discussed using data obtained in experimental, field, and simulation studies. Benzene toluene, styrene, 1,1,1-trichloroethylene, and tetrachloroethylene are taken as examples of solvents showing various toxicokinetic properties. Finally, breath analysis is compared with other biological monitoring methods.
呼吸分析已在许多场合被提出用于监测溶剂暴露情况。然而，由于方法本身（采样和分析）存在困难以及缺乏其与暴露剂量关系的数据，它仍很少被常规使用。本文简要回顾、比较并讨论了当今可用的各种方法。重点是同时使用二氧化碳作为呼吸指标。介绍了两种采用这种方法的方法。利用在实验、现场和模拟研究中获得的数据，讨论了呼吸分析用于职业暴露监测的优缺点。以苯、甲苯、苯乙烯、1,1,1 - 三氯乙烯和四氯乙烯为例，这些溶剂具有不同的毒代动力学特性。最后，将呼吸分析与其他生物监测方法进行了比较。
