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阿莫西林和L.叶提取物对口腔病原菌的抗菌及抗生物膜作用

The Antibacterial and Antibiofilm Effect of Amoxicillin and L. Leaves Extract on Oral Pathogens.

作者信息

Soesanto Sheila, Hepziba Evangelista Rachel, Widyarman Armelia Sari

机构信息

Department of Pharmacology, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia.

Undergraduate Student, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia.

出版信息

Contemp Clin Dent. 2023 Apr-Jun;14(2):145-151. doi: 10.4103/ccd.ccd_399_22. Epub 2023 Jun 30.

DOI:10.4103/ccd.ccd_399_22
PMID:37547439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10399797/
Abstract

OBJECTIVE

This study aimed to determine the antibacterial and antibiofilm effects of amoxicillin combined with extract of L. leaves against and .

MATERIALS AND METHODS

This was an experimental laboratory study with a posttest-only control group design. An antibacterial test using the plate count method and an antibiofilm test using the microtiter plate biofilm assay method were conducted. The research samples comprised extract of L. leaves with a concentration of 100%; amoxicillin and extract concentrations of 3.125%, 6.25%, 12.5%, 25%, 50%, and 100%; and amoxicillin. Dimethyl sulfoxide served as a negative control and co-amoxiclav served as a positive control.

RESULTS

The combination of amoxicillin and the extract exhibited an antibacterial effect against at a concentration of 12.5% and higher and more effective than co-amoxiclac at a concentration of 3.125% and higher. In the antibiofilm test, the combination of amoxicillin and the extract at a concentration of 25% after 1 h of incubation and a concentration of 6.25% after 3 h of incubation inhibited . The inhibition of biofilms at a concentration of 100% after 24 h of incubation was as effective as that of co-amoxiclav. The extract at a concentration of 25% over the entire incubation period showed more potent inhibition against the biofilm than co-amoxiclav.

CONCLUSIONS

The ethanolic extract of L. leaves and the combination of amoxicillin and the extract have the potential to inhibit the growth and formation of and biofilms.

摘要

目的

本研究旨在确定阿莫西林与[植物名称]叶提取物联合使用对[细菌名称1]和[细菌名称2]的抗菌及抗生物膜作用。

材料与方法

这是一项采用仅后测对照组设计的实验性实验室研究。进行了使用平板计数法的抗菌试验和使用微量滴定板生物膜检测法的抗生物膜试验。研究样本包括浓度为100%的[植物名称]叶提取物；阿莫西林以及浓度为3.125%、6.25%、12.5%、25%、50%和100%的提取物与阿莫西林的组合；还有阿莫西林。二甲基亚砜用作阴性对照，克拉维酸阿莫西林用作阳性对照。

结果

阿莫西林与提取物的组合在浓度为12.5%及更高时对[细菌名称1]表现出抗菌作用，且在浓度为3.125%及更高时比克拉维酸阿莫西林更有效。在抗生物膜试验中，孵育1小时后浓度为25%以及孵育3小时后浓度为6.25%的阿莫西林与提取物的组合抑制了[细菌名称2]。孵育24小时后浓度为100%的提取物对[细菌名称2]生物膜的抑制效果与克拉维酸阿莫西林相同。在整个孵育期内，浓度为25%的提取物对[细菌名称2]生物膜的抑制作用比克拉维酸阿莫西林更强。

结论

[植物名称]叶的乙醇提取物以及阿莫西林与该提取物的组合有潜力抑制[细菌名称1]和[细菌名称2]生物膜的生长和形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/f67edc49a75a/CCD-14-145-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/9feae10fc713/CCD-14-145-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/1967347cbf4e/CCD-14-145-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/43750ed69064/CCD-14-145-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/9e3315bf7f57/CCD-14-145-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/d16535ed1676/CCD-14-145-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/34ed72f6b412/CCD-14-145-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/25ec1871d31d/CCD-14-145-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/da9a5c421177/CCD-14-145-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/f67edc49a75a/CCD-14-145-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/9feae10fc713/CCD-14-145-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/1967347cbf4e/CCD-14-145-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/43750ed69064/CCD-14-145-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/9e3315bf7f57/CCD-14-145-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/d16535ed1676/CCD-14-145-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/34ed72f6b412/CCD-14-145-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/25ec1871d31d/CCD-14-145-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/da9a5c421177/CCD-14-145-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9498/10399797/f67edc49a75a/CCD-14-145-g009.jpg

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