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一例甘草浸制大麻导致表观盐皮质激素过多综合征的病例。

A Case of Liquorice-Infused Marijuana Causing Syndrome of Apparent Mineralocorticoid Excess.

作者信息

Latif Asnia, Naqi Muniba, McAnally James F

机构信息

Department of Internal Medicine, Rutgers NJMS Trinitas Regional Medical Center, Elizabeth, New Jersey, USA.

Department of Nephrology, Rutgers NJMS Trinitas Regional Medical Center, Elizabeth, New Jersey, USA.

出版信息

Eur J Case Rep Intern Med. 2023 Aug 21;10(9):003991. doi: 10.12890/2023_003991. eCollection 2023.

Abstract

UNLABELLED

Marijuana has long been used both for recreational and medicinal purposes. Most of the available forms of marijuana contain additives such as liquorice to enhance its flavour. Liquorice increases the amounts of cortisol in the body and produces metabolic abnormalities seen in primary hyperaldosteronism. Liquorice extracts are mixed with marijuana in the same way as for tobacco. We describe a case of apparent mineralocorticoid excess due to excessive smoking of liquorice-laced marijuana. To our knowledge, this is the first reported case of apparent mineralocorticoid excess caused by marijuana use.

LEARNING POINTS

First report of liquorice-laced marijuana causing syndrome of apparent mineralocorticoid excess (SAME).Since its legalisation, marijuana is reported to be the most used substance second only to alcohol. With the increased availability of marijuana, the health care providers and consumers must be cognisant of its side effects.It is a dose-dependent phenomenon. The effects vary from minor clinical symptoms to fatal arrhythmias based on the amount consumed.

摘要

未标注

长期以来,大麻一直被用于娱乐和药用目的。大多数现有的大麻形式都含有添加剂,如甘草,以增强其风味。甘草会增加体内皮质醇的含量,并产生原发性醛固酮增多症中出现的代谢异常。甘草提取物与大麻的混合方式与烟草相同。我们描述了一例因过量吸食掺有甘草的大麻而导致明显盐皮质激素过多的病例。据我们所知,这是第一例因使用大麻导致明显盐皮质激素过多的报告病例。

学习要点

首次报告掺有甘草的大麻导致明显盐皮质激素过多综合征(SAME)。自合法化以来,据报道大麻是仅次于酒精的最常用物质。随着大麻的可得性增加,医疗保健提供者和消费者必须认识到其副作用。这是一种剂量依赖性现象。根据摄入量的不同,影响从轻微的临床症状到致命的心律失常不等。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b00/10482139/0dbec4f2f121/3991_Fig1.jpg

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