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将预训练的卷积神经网络进行适配,以提高乳腺图像中的异常检测和分类。

Adapting the pre-trained convolutional neural networks to improve the anomaly detection and classification in mammographic images.

机构信息

Department of Information Technology, Faculty of Computers and Artificial Intelligence, Damietta University, Damietta, 34517, Egypt.

Department of Computer and Information Science, Linköping University, Linköping, Sweden.

出版信息

Sci Rep. 2023 Sep 9;13(1):14877. doi: 10.1038/s41598-023-41633-0.

DOI:10.1038/s41598-023-41633-0
PMID:37689757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10492817/
Abstract

Mortality from breast cancer (BC) is among the top causes of cancer death in women. BC can be effectively treated when diagnosed early, improving the likelihood that a patient will survive. BC masses and calcification clusters must be identified by mammography in order to prevent disease effects and commence therapy at an early stage. A mammography misinterpretation may result in an unnecessary biopsy of the false-positive results, lowering the patient's odds of survival. This study intends to improve breast mass detection and identification in order to provide better therapy and reduce mortality risk. A new deep-learning (DL) model based on a combination of transfer-learning (TL) and long short-term memory (LSTM) is proposed in this study to adequately facilitate the automatic detection and diagnosis of the BC suspicious region using the 80-20 method. Since DL designs are modelled to be problem-specific, TL applies the knowledge gained during the solution of one problem to another relevant problem. In the presented model, the learning features from the pre-trained networks such as the squeezeNet and DenseNet are extracted and transferred with the features that have been extracted from the INbreast dataset. To measure the proposed model performance, we selected accuracy, sensitivity, specificity, precision, and area under the ROC curve (AUC) as our metrics of choice. The classification of mammographic data using the suggested model yielded overall accuracy, sensitivity, specificity, precision, and AUC values of 99.236%, 98.8%, 99.1%, 96%, and 0.998, respectively, demonstrating the model's efficacy in detecting breast tumors.

摘要

乳腺癌(BC)的死亡率是女性癌症死亡的主要原因之一。早期诊断可以有效治疗 BC,提高患者的生存率。通过乳房 X 光摄影术可以识别乳腺癌肿块和钙化簇,以防止疾病恶化并尽早开始治疗。如果对乳房 X 光摄影术的解释有误,可能会导致对假阳性结果进行不必要的活检,从而降低患者的生存机会。本研究旨在改进乳房肿块的检测和识别,以提供更好的治疗并降低死亡率风险。本研究提出了一种基于迁移学习(TL)和长短期记忆(LSTM)相结合的新深度学习(DL)模型,以便使用 80-20 方法充分促进 BC 可疑区域的自动检测和诊断。由于 DL 设计是针对特定问题的,因此 TL 将在解决一个问题过程中获得的知识应用于另一个相关问题。在提出的模型中,从预先训练的网络(如 squeezeNet 和 DenseNet)中提取学习特征,并与从 INbreast 数据集提取的特征进行迁移。为了衡量所提出模型的性能,我们选择了准确性、敏感度、特异性、精度和 ROC 曲线下面积(AUC)作为我们的选择指标。使用建议的模型对乳房 X 光摄影术数据进行分类,其总体准确率、敏感度、特异性、精度和 AUC 值分别为 99.236%、98.8%、99.1%、96%和 0.998,证明了该模型在检测乳房肿瘤方面的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/665e772f3ebe/41598_2023_41633_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/665e772f3ebe/41598_2023_41633_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/c6eb5f249c4b/41598_2023_41633_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/2a6b8dd14a37/41598_2023_41633_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/3067ed75a881/41598_2023_41633_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/e48dfcc124fa/41598_2023_41633_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/6ec01063420b/41598_2023_41633_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/5f86b455ef27/41598_2023_41633_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/24dda7de4ba2/41598_2023_41633_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/9cfcd3ed8bf7/41598_2023_41633_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5fb/10492817/665e772f3ebe/41598_2023_41633_Fig9_HTML.jpg

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