College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China.
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
Molecules. 2023 Oct 12;28(20):7039. doi: 10.3390/molecules28207039.
Large bone defects due to trauma, infections, and tumors are difficult to heal spontaneously by the body's repair mechanisms and have become a major hindrance to people's daily lives and economic development. However, autologous and allogeneic bone grafts, with their lack of donors, more invasive surgery, immune rejection, and potential viral transmission, hinder the development of bone repair. Hydrogel tissue bioengineered scaffolds have gained widespread attention in the field of bone repair due to their good biocompatibility and three-dimensional network structure that facilitates cell adhesion and proliferation. In addition, loading natural products with nanoparticles and incorporating them into hydrogel tissue bioengineered scaffolds is one of the most effective strategies to promote bone repair due to the good bioactivity and limitations of natural products. Therefore, this paper presents a brief review of the application of hydrogels with different gel-forming properties, hydrogels with different matrices, and nanoparticle-loaded natural products loaded and incorporated into hydrogels for bone defect repair in recent years.
由于创伤、感染和肿瘤导致的大骨缺损，很难通过身体的修复机制自发愈合，这已经成为人们日常生活和经济发展的主要障碍。然而，自体和同种异体骨移植由于缺乏供体、更具侵入性的手术、免疫排斥和潜在的病毒传播，阻碍了骨修复的发展。水凝胶组织生物工程支架由于具有良好的生物相容性和有利于细胞黏附增殖的三维网络结构，在骨修复领域受到广泛关注。此外，将天然产物加载到纳米颗粒中并将其掺入水凝胶组织生物工程支架中是促进骨修复最有效的策略之一，因为天然产物具有良好的生物活性和局限性。因此，本文简要综述了近年来不同凝胶形成特性的水凝胶、不同基质的水凝胶以及负载和掺入水凝胶中的纳米颗粒负载天然产物在骨缺损修复中的应用。
