大肠杆菌中氨酰基转移核糖核酸合成酶和转移核糖核酸生物合成的调控。VI. 谷氨酰胺基转移核糖核酸合成酶和谷氨酰胺转移核糖核酸水平升高的突变体。
Regulation of the biosynthesis of aminoacyl-transfer ribonucleic acid synthetases and of transfer ribonucleic acid in Escherichia coli. VI. Mutants with increased levels of glutaminyl-transfer ribonucleic acid synthetase and of glutamine transfer ribonucleic acid.
作者信息
Cheung A, Morgan S, Low K B, Söll D
出版信息
J Bacteriol. 1979 Jul;139(1):176-84. doi: 10.1128/jb.139.1.176-184.1979.
Abstract
Spontaneous revertants of a temperature-sensitive Escherichia coli strain bearing a thermolabile glutaminyl-transfer ribonucleic acid (tRNA) synthetase have been selected for growth at 45 degrees C. Among 10 revertants still containing the thermolabile enzyme, 2 interesting strains were found. One strain has a fivefold elevated level of the thermolabile glutaminyl-tRNA synthetase; the genetic locus, glnR, responsible for this effect maps at min 24, far from glnS, the structural gene of the enzyme. In the other strain the levels of tRNA Gln and several other tRNAs are twice as high as in the parental strain; the locus responsible, glnU, maps at min 59.5 on the E. coli map.
摘要
已筛选出一株携带热不稳定谷氨酰胺转移核糖核酸（tRNA）合成酶的温度敏感型大肠杆菌菌株的自发回复突变体，使其能在45℃下生长。在10个仍含有热不稳定酶的回复突变体中，发现了2个有趣的菌株。其中一个菌株的热不稳定谷氨酰胺-tRNA合成酶水平提高了五倍；负责此效应的基因座glnR位于24分钟处，与该酶的结构基因glnS距离很远。在另一个菌株中，tRNA Gln和其他几种tRNA的水平是亲本菌株的两倍；负责此效应的基因座glnU位于大肠杆菌图谱的59.5分钟处。
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