喂食卵清蛋白的小鼠中，口服耐受性在体液免疫反应和细胞介导免疫反应方面的持续性有所不同。
Persistence of oral tolerance in mice fed ovalbumin is different for humoral and cell-mediated immune responses.
作者信息
Strobel S, Ferguson A
出版信息
Immunology. 1987 Feb;60(2):317-8.
Abstract
The duration of oral tolerance after a single feed of OVA at the age of 6 weeks was studied in BDF1 mice. Significant suppression of systemic antibody responses was present 3 months later, but not at 6.5 months; in contrast, at all times studied from 2 weeks to 17 months after an OVA feed there was suppression of systemic CMI to OVA as measured by an in vivo skin test. This indicates that the two limbs of the immune response differ in the factors responsible for the maintenance of oral tolerance.
摘要
在6周龄时单次喂食卵清蛋白（OVA）后，研究了BDF1小鼠口服耐受的持续时间。3个月后出现了对全身抗体反应的显著抑制，但6.5个月时未出现；相反，在OVA喂食后2周-17个月的所有研究时间点，通过体内皮肤试验测量发现，对OVA的全身细胞介导免疫（CMI）均受到抑制。这表明免疫反应的两个分支在维持口服耐受的因素方面存在差异。
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本文引用的文献
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Systemic tolerance and secretory immunity after oral immunization.口服免疫后的全身耐受性和分泌性免疫
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Immune responses to fed protein antigens in mice. 3. Systemic tolerance or priming is related to age at which antigen is first encountered.小鼠对摄入蛋白质抗原的免疫反应。3. 全身耐受性或致敏与首次接触抗原的年龄有关。
Pediatr Res. 1984 Jul;18(7):588-94. doi: 10.1203/00006450-198407000-00004.
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Cellular events during induction of immunologic unresponsiveness in adult mice.成年小鼠免疫无反应性诱导过程中的细胞事件。
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Inhibition of homocytotropic antibody responses in adult inbred mice by previous feeding of the specific antigen.通过预先投喂特定抗原来抑制成年近交系小鼠中的亲同种细胞抗体反应。
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Tolerance, the thymus, and suppressor T cells.耐受性、胸腺与抑制性T细胞。
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Immunologic tolerance and immunopathology.
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