Flaisher-Grinberg Shlomit
Psychology Department, Saint Francis University, Loretto, PA 15940.
J Undergrad Neurosci Educ. 2023 Dec 17;22(1):A37-A44. doi: 10.59390/JWNQ5957. eCollection 2023 Fall.
Psychopharmacological concepts such as pharmacokinetics, pharmacodynamics and drug interactions can be difficult to illustrate within the college classroom. In this demonstration, students consume poppy seed-containing food items, assess opioid content in their oral fluid using commercial drug test kits, and relate the findings to learned materials, its real-life applications, and relevant societal implications. This demonstration can clarify processes such as drug absorption, distribution, metabolism, and excretion (ADME), broaden the review of information relevant to opioids mechanisms of action, and facilitate the discussion of topics such as drug abuse, dependence, and addiction, as well as drug development, testing, policy, and enforcement. Instructors can employ different experimental designs, create dose-dependent/timeline detection plots, or allow students to construct their own experiments, assessing possible mediators of opioid detection. The demonstration can also be utilized to discuss scientific myths, truths, data misinterpretation and misrepresentation. Several optional protocols are provided, required materials are indicated, and discussion points are suggested.
诸如药代动力学、药效学和药物相互作用等精神药理学概念在大学课堂上可能难以阐释。在本次演示中，学生食用含罂粟籽的食品，使用商用药物检测试剂盒评估其口腔液中的阿片类物质含量，并将研究结果与所学材料、其实际应用以及相关社会影响联系起来。本次演示可以阐明药物吸收、分布、代谢和排泄（ADME）等过程，拓宽对与阿片类物质作用机制相关信息的复习，促进对药物滥用、依赖和成瘾以及药物开发、测试、政策和执法等主题的讨论。教师可以采用不同的实验设计，创建剂量依赖性/时间线检测图，或者让学生自行设计实验，评估阿片类物质检测的可能介质。该演示还可用于讨论科学神话、真相、数据误解和歪曲。文中提供了几个可选方案，标明了所需材料，并给出了讨论要点。
