成年慢性腹泻和便秘患者甘油三酯葡萄糖指数的评估
Assessment of the triglyceride glucose index in adult patients with chronic diarrhea and constipation.
作者信息
Zhu Jing-Yi, Liu Mu-Yun, Sun Chang
机构信息
Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Department of Gastroenterology, Navy No. 905 Hospital, Naval Medical University, Shanghai 200433, China.
出版信息
World J Clin Cases. 2024 Feb 26;12(6):1094-1103. doi: 10.12998/wjcc.v12.i6.1094.
BACKGROUND
Accumulating evidence suggests that the gut microbiome is involved in the pathogenesis of insulin resistance (IR). However, the link between two of the most prevalent bowel disorders, chronic diarrhea and constipation, and the triglyceride glucose (TyG) index, a marker of IR, has not yet been investigated.
AIM
To investigate the potential association between TyG and the incidence of chronic diarrhea and constipation.
METHODS
This cross-sectional study enrolled 2400 participants from the National Health and Nutrition Examination Survey database from 2009-2010. TyG was used as an exposure variable, with chronic diarrhea and constipation as determined by the Bristol Stool Form Scale used as the outcome variables. A demographic investigation based on TyG quartile subgroups was performed. The application of multivariate logistic regression models and weighted generalized additive models revealed potential correlations between TyG, chronic diarrhea, and constipation. Subgroup analyses were performed to examine the stability of any potential associations.
RESULTS
In the chosen sample, chronic diarrhea had a prevalence of 8.00%, while chronic constipation had a prevalence of 8.04%. In multiple logistic regression, a more prominent positive association was found between TyG and chronic diarrhea, particularly in model 1 (OR = 1.45; 95%CI: 1.17-1.79, = 0.0007) and model 2 (OR = 1.40; 95%CI: 1.12-1.76, = 0.0033). No definite association was observed between the TyG levels and chronic constipation. The weighted generalized additive model findings suggested a more substantial positive association with chronic diarrhea when TyG was less than 9.63 (OR = 1.89; 95%CI: 1.05-3.41, = 0.0344), and another positive association with chronic constipation when it was greater than 8.2 (OR = 1.74; 95%CI: 1.02-2.95, = 0.0415). The results of the subgroup analyses further strengthen the extrapolation of these results to a wide range of populations.
CONCLUSION
Higher TyG levels were positively associated with abnormal bowel health.
背景
越来越多的证据表明，肠道微生物群与胰岛素抵抗（IR）的发病机制有关。然而，两种最常见的肠道疾病——慢性腹泻和便秘，与IR的标志物甘油三酯葡萄糖（TyG）指数之间的联系尚未得到研究。
目的
研究TyG与慢性腹泻和便秘发病率之间的潜在关联。
方法
这项横断面研究纳入了2009 - 2010年美国国家健康与营养检查调查数据库中的2400名参与者。TyG用作暴露变量，根据布里斯托大便分类法确定的慢性腹泻和便秘用作结果变量。对基于TyG四分位数亚组进行了人口统计学调查。多元逻辑回归模型和加权广义相加模型的应用揭示了TyG、慢性腹泻和便秘之间的潜在相关性。进行亚组分析以检验任何潜在关联的稳定性。
结果
在所选样本中，慢性腹泻的患病率为8.00%，而慢性便秘的患病率为8.04%。在多元逻辑回归中，发现TyG与慢性腹泻之间存在更显著的正相关，特别是在模型1（OR = 1.45；95%CI：1.17 - 1.79，P = 0.0007）和模型2（OR = 1.40；95%CI：1.12 - 1.76，P = 0.0033）中。未观察到TyG水平与慢性便秘之间有明确关联。加权广义相加模型的结果表明，当TyG小于9.63时与慢性腹泻有更显著的正相关（OR = 1.89；95%CI：1.05 - 3.41，P = 0.0344），当TyG大于8.2时与慢性便秘有另一个正相关（OR = 1.74；95%CI：1.02 - 2.95，P = 0.0415）。亚组分析结果进一步加强了将这些结果外推至广泛人群的推断。
结论
较高的TyG水平与肠道健康异常呈正相关。
Zotero 插件