用于基于医学影像的新冠病毒检测与诊断的机器学习

Machine learning for medical imaging-based COVID-19 detection and diagnosis.

作者信息

Rehouma Rokaya, Buchert Michael, Chen Yi-Ping Phoebe

机构信息

School of Cancer Medicine La Trobe University Melbourne Victoria Australia.

Tumour Microenvironment and Cancer Signaling Group Olivia Newton-John Cancer Research Institute Melbourne Victoria Australia.

出版信息

Int J Intell Syst. 2021 Sep;36(9):5085-5115. doi: 10.1002/int.22504. Epub 2021 May 31.

Abstract

The novel coronavirus disease 2019 (COVID-19) is considered to be a significant health challenge worldwide because of its rapid human-to-human transmission, leading to a rise in the number of infected people and deaths. The detection of COVID-19 at the earliest stage is therefore of paramount importance for controlling the pandemic spread and reducing the mortality rate. The real-time reverse transcription-polymerase chain reaction, the primary method of diagnosis for coronavirus infection, has a relatively high false negative rate while detecting early stage disease. Meanwhile, the manifestations of COVID-19, as seen through medical imaging methods such as computed tomography (CT), radiograph (X-ray), and ultrasound imaging, show individual characteristics that differ from those of healthy cases or other types of pneumonia. Machine learning (ML) applications for COVID-19 diagnosis, detection, and the assessment of disease severity based on medical imaging have gained considerable attention. Herein, we review the recent progress of ML in COVID-19 detection with a particular focus on ML models using CT and X-ray images published in high-ranking journals, including a discussion of the predominant features of medical imaging in patients with COVID-19. Deep Learning algorithms, particularly convolutional neural networks, have been utilized widely for image segmentation and classification to identify patients with COVID-19 and many ML modules have achieved remarkable predictive results using datasets with limited sample sizes.

摘要

2019年新型冠状病毒病(COVID-19)因其在人与人之间的快速传播,导致感染人数和死亡人数上升,被认为是全球一项重大的健康挑战。因此,尽早检测出COVID-19对于控制疫情传播和降低死亡率至关重要。实时逆转录聚合酶链反应作为冠状病毒感染的主要诊断方法,在检测早期疾病时假阴性率相对较高。同时,通过计算机断层扫描(CT)、X光片(X射线)和超声成像等医学成像方法观察到的COVID-19表现,呈现出与健康病例或其他类型肺炎不同的个体特征。基于医学成像的机器学习(ML)在COVID-19诊断、检测和疾病严重程度评估方面的应用受到了广泛关注。在此,我们回顾了ML在COVID-19检测方面的最新进展,特别关注在高影响力期刊上发表的使用CT和X光图像的ML模型,包括对COVID-19患者医学成像主要特征的讨论。深度学习算法,特别是卷积神经网络,已被广泛用于图像分割和分类以识别COVID-19患者,并且许多ML模块使用样本量有限的数据集取得了显著的预测结果。

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