Okudo Adaora C, Babalola Olufemi E
Rachel Eye Center, Garki. Area 11, Abuja, Nigeria.
Niger Med J. 2023 Jan 25;63(1):71-76. doi: 10.60787/NMJ-63-1-83. eCollection 2022 Jan-Feb.
Central Corneal Thickness (CCT) measurement is useful in the management of glaucoma, ocular hypertension, corneal lesions and kerato-refractive surgeries. The study aims to compare the CCT measurements between Ultrasound Sonography (USS) and Optical Coherence Tomography (OCT), to analyze correlation and agreement between these instruments as well as repeatability of each instrument.
A cross sectional comparative study carried in 100 eyes of 50 patients attending Rachel Eye Center in Abuja from January to March 2021. The CCT were taken using the USS and OCT. CCT was measured using the Pachscan ultrasound and the Optovue machine utilised for the OCT technique. Data was analysed using SPSS version 20 using Paired Sample t Test, Pearson's correlation, Interclass Correlation and Bland Altman Methods.
Patients were aged between 18 and 79 (mean age of 39.1), 72 males and 28 females. The mean CCT was 537.36 ±33.26 and 510.94 ±33.13 for USS and OCT respectively with a mean difference of (26.42±9.53 p<0.001). There was a very strong correlation of the 2 sets of measurement r = 0.997 p<0.001. There was a high average mean intraclass correlation coefficient of 0.843 between the two instruments and this was excellent (0.961) within the 95 percentile upper limit but poor in the (0.096) lower limit. There was a high correlation and no statistical significant difference in the comparing repeated mean USS and OCT measurements. There was an excellent average mean Intraclass Correlation Coefficient of 0.999/0.997 for the repeated OCT and USS values and this was found to be excellent(0.999/0.998) within the 95 percentile upper limit and (0.997/0.994)lower limit respectively.
We find that measurements of CCT using the Pachscan ultrasound and the Optovue OCT correlate well, but the mean Pachscan measures were significantly higher than Optovue measures.
中央角膜厚度（CCT）测量在青光眼、高眼压症、角膜病变及角膜屈光手术的管理中具有重要作用。本研究旨在比较超声生物显微镜（USS）与光学相干断层扫描（OCT）测量CCT的结果，分析这两种仪器测量结果之间的相关性和一致性以及每种仪器的可重复性。
于2021年1月至3月在阿布贾瑞秋眼科中心对50例患者的100只眼进行了一项横断面比较研究。使用USS和OCT测量CCT。采用Pachscan超声测量CCT，使用Optovue机器进行OCT测量。使用SPSS 20版软件，采用配对样本t检验、Pearson相关性分析、组内相关分析和Bland Altman方法对数据进行分析。
患者年龄在18至79岁之间（平均年龄39.1岁），男性72例，女性28例。USS测量的平均CCT为537.36±33.26，OCT测量的平均CCT为510.94±33.13，平均差值为（26.42±9.53，p<0.001）。两组测量结果具有非常强的相关性，r = 0.997，p<0.001。两种仪器之间的平均组内相关系数较高，为0.843，在95%百分位数上限内表现出色（0.961），但在较低限（0.096）时较差。比较重复测量的USS和OCT平均结果时，具有高度相关性且无统计学显著差异。重复测量的OCT和USS值的平均组内相关系数分别为0.999/0.997，在95%百分位数上限内表现出色（分别为0.999/0.998），在较低限（0.997/0.994）时也表现出色。
我们发现使用Pachscan超声和Optovue OCT测量CCT的结果具有良好的相关性，但Pachscan测量的平均值显著高于Optovue测量的平均值。
