National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
BMC Ophthalmol. 2024 Jun 28;24(1):273. doi: 10.1186/s12886-024-03532-4.
Glaucoma is a worldwide eye disease that can cause irreversible vision loss. Early detection of glaucoma is important to reduce vision loss, and retinal fundus image examination is one of the most commonly used solutions for glaucoma diagnosis due to its low cost. Clinically, the cup-disc ratio of fundus images is an important indicator for glaucoma diagnosis. In recent years, there have been an increasing number of algorithms for segmentation and recognition of the optic disc (OD) and optic cup (OC), but these algorithms generally have poor universality, segmentation performance, and segmentation accuracy.
By improving the YOLOv8 algorithm for segmentation of OD and OC. Firstly, a set of algorithms was designed to adapt the REFUGE dataset's result images to the input format of the YOLOv8 algorithm. Secondly, in order to improve segmentation performance, the network structure of YOLOv8 was improved, including adding a ROI (Region of Interest) module, modifying the bounding box regression loss function from CIOU to Focal-EIoU. Finally, by training and testing the REFUGE dataset, the improved YOLOv8 algorithm was evaluated.
The experimental results show that the improved YOLOv8 algorithm achieves good segmentation performance on the REFUGE dataset. In the OD and OC segmentation tests, the F1 score is 0.999.
We improved the YOLOv8 algorithm and applied the improved model to the segmentation task of OD and OC in fundus images. The results show that our improved model is far superior to the mainstream U-Net model in terms of training speed, segmentation performance, and segmentation accuracy.
青光眼是一种全球性眼病,可导致不可逆转的视力丧失。早期发现青光眼对于减少视力丧失非常重要,眼底图像检查由于成本低,是青光眼诊断最常用的方法之一。临床上,眼底图像的杯盘比是青光眼诊断的一个重要指标。近年来,针对视盘(OD)和视杯(OC)的分割和识别算法越来越多,但这些算法普遍通用性差、分割性能和分割精度不高。
通过改进 YOLOv8 算法进行 OD 和 OC 的分割。首先,设计了一组算法,以适应 REFUGE 数据集的结果图像到 YOLOv8 算法的输入格式。其次,为了提高分割性能,改进了 YOLOv8 的网络结构,包括添加 ROI(感兴趣区域)模块,将边界框回归损失函数从 CIOU 改为 Focal-EIoU。最后,通过对 REFUGE 数据集进行训练和测试,评估改进后的 YOLOv8 算法。
实验结果表明,改进后的 YOLOv8 算法在 REFUGE 数据集上取得了良好的分割性能。在 OD 和 OC 分割测试中,F1 得分达到 0.999。
我们改进了 YOLOv8 算法,并将改进后的模型应用于眼底图像的 OD 和 OC 分割任务。结果表明,我们改进的模型在训练速度、分割性能和分割精度方面均优于主流的 U-Net 模型。