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艰难梭菌毒素A和B对兔回肠和结肠的作用。

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.

作者信息

Mitchell T J, Ketley J M, Haslam S C, Stephen J, Burdon D W, Candy D C, Daniel R

出版信息

Gut. 1986 Jan;27(1):78-85. doi: 10.1136/gut.27.1.78.

DOI:10.1136/gut.27.1.78
PMID:3949240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1433160/
Abstract

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

摘要

研究了纯化的毒素A和部分纯化的毒素B对兔回肠和结肠的作用。毒素A导致组织损伤，随后两种组织均出现通透性改变和液体蓄积。毒素A并未使结肠的通透性增加到回肠所观察到的程度；分泌的液体中血浆源性蛋白质含量较低。毒素B对两种组织均无作用。发现艰难梭菌粗毒素的分泌和组织损伤特性归因于毒素A。

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Clinical and laboratory observations in Clostridium difficile colitis.艰难梭菌结肠炎的临床及实验室观察
Am J Clin Nutr. 1980 Nov;33(11 Suppl):2521-6. doi: 10.1093/ajcn/33.11.2521.
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Comparison of two toxins produced by Clostridium difficile.艰难梭菌产生的两种毒素的比较。
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Myoelectric effects of Clostridium difficile: motility-altering factors distinct from its cytotoxin and enterotoxin in rabbits.艰难梭菌的肌电效应：家兔体内不同于其细胞毒素和肠毒素的运动改变因子。
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Increased intestinal permeability and downregulation of absorptive ion transporters , , and contribute to diarrhea during infection.感染期间，肠道通透性增加和吸收性离子转运体 、 、 的下调导致腹泻。
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Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease.宿主山梨糖醇和细菌山梨糖醇利用促进炎症性肠病中的艰难梭菌感染。
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Using a ligate intestinal loop mouse model to investigate Clostridioides difficile adherence to the intestinal mucosa in aged mice.采用结扎肠袢小鼠模型研究艰难梭菌在老年小鼠肠道黏膜的黏附作用。
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The Relative Role of Toxins A and B in the Virulence of .毒素A和毒素B在……毒力中的相对作用 。 （原文句子不完整）
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Semin Neonatol. 1997 Nov;2(4):255-262. doi: 10.1016/S1084-2756(97)80032-2. Epub 2006 Dec 24.
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