Yang Lihang, Xie Diya, Liu Fengmin, Lin Jiaying, Lin Xin, Chen Yuquan, Zhang Kun
Department of Endocrinology, Fuzhou First General Hospital Affiliated With Fujian Medical University, Fuzhou, Fujian, China.
Department of General Surgery, Fuzhou First General Hospital Affiliated With Fujian Medical University, Fuzhou, Fujian, China.
J Diabetes. 2025 Jan;17(1):e70043. doi: 10.1111/1753-0407.70043.
Type 2 diabetes mellitus (T2DM) contributes to the heavy burden, but there lacks latest and comprehensive global research on the burden of T2DM attributable to low physical activity (LPA). This study aimed to quantify the global and regional burden of T2DM attributable to LPA from 1990 to 2021.
We utilized data including disability-adjusted life years (DALYs), mortality, age-standardized disability-adjusted life years (ASDR), and age-standardized mortality rates (ASMR) from the Global Burden of Disease (GBD) 2021. We assessed the burden across different ages, genders, and sociodemographic index (SDI). Joinpoint regression analysis was applied to estimated average annual percent change (AAPC).
Between 1990 and 2021, DALYs and mortality of T2DM attributable to LPA increased rapidly. There was an increase in the ASDR and ASMR, with AAPC of 1.09 (95% CI: 1.03-1.16) and 0.32 (95% CI: 0.2-0.43), which was increased faster in males. Low-middle SDI countries have the highest ASDR and highest ASMR. The global PAF for ASDR and ASMR in 2021 is 7.38% and 9.45%. A U-shaped drift pattern was observed in most SDI quintiles in APC model. Population growth is a major contributor to the burden of T2DM, especially in countries with low SDI. Epidemiological changes also play an important role in DALYs and mortality. A negative correlation existed between SDI and both ASMR and ASDR.
Between 1990 and 2021, there was a marked rise in the global burden of T2DM associated with LPA. The findings lay the groundwork for informed decision-making a public health and healthcare delivery.
2型糖尿病（T2DM）造成了沉重负担，但缺乏关于低体力活动（LPA）所致T2DM负担的最新全面全球研究。本研究旨在量化1990年至2021年期间LPA所致T2DM的全球和区域负担。
我们利用了来自《2021年全球疾病负担》（GBD 2021）的数据，包括伤残调整生命年（DALYs）、死亡率、年龄标准化伤残调整生命年（ASDR）和年龄标准化死亡率（ASMR）。我们评估了不同年龄、性别和社会人口指数（SDI）的负担情况。采用Joinpoint回归分析来估计年均变化百分比（AAPC）。
1990年至2021年期间，LPA所致T2DM的DALYs和死亡率迅速上升。ASDR和ASMR有所增加，AAPC分别为1.09（95%CI：1.03 - 1.16）和0.32（95%CI：0.2 - 0.43），男性上升更快。低中SDI国家的ASDR和ASMR最高。2021年全球ASDR和ASMR的人群归因分数（PAF）分别为7.38%和9.45%。在APC模型中，大多数SDI五分位数观察到U型漂移模式。人口增长是T2DM负担的主要贡献因素，尤其是在低SDI国家。流行病学变化在DALYs和死亡率方面也发挥着重要作用。SDI与ASMR和ASDR均呈负相关。
1990年至2021年期间，与LPA相关的T2DM全球负担显著上升。这些发现为公共卫生和医疗服务的明智决策奠定了基础。
