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四种新型非结核分枝杆菌菌种：[具体菌种1]新种、[具体菌种2]新种、[具体菌种3]新种和[具体菌种4]新种，从丹麦历史菌株保藏库中复苏得到。

Four novel nontuberculous mycobacteria species: sp. nov., sp. nov., sp. nov. and sp. nov. revived from a historical Danish strain collection.

作者信息

Iversen Xenia Emilie Sinding, Rasmussen Erik Michael, Folkvardsen Dorte Bek, Svensson Erik, Meehan Conor J, Jørgensen René, Norman Anders, Lillebaek Troels

机构信息

International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark.

Department of Biosciences, Nottingham Trent University, Nottingham, UK.

出版信息

Int J Syst Evol Microbiol. 2025 Jan;75(1). doi: 10.1099/ijsem.0.006620.

DOI:10.1099/ijsem.0.006620
PMID:39773688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11706282/
Abstract

Four novel nontuberculous mycobacteria were discovered from a historical strain collection at the International Reference Laboratory of Mycobacteriology at Statens Serum Institut in Copenhagen, Denmark. Phylogenetic analysis combining the 16S , internal transcribed spacer and 23S elements, as well as a single-copy core-gene (, , and ) analysis of these freeze-dried mycobacteria, clinically isolated from gastric lavage samples between 1948 and 1955, showed to be associated with type strains grouping within the Terra and Fortuitum-Vaccae clade. Phenotypic characteristics, biochemical properties and fatty acid and mycolic acid profiles supported the classification as novel strains. A genomic comparison to the closest related type strain was done by calculating average nucleotide identity and DNA:DNA hybridization values, which showed 87.9% and 33.0% for Mu0050, 85.2% and 27.4% for Mu0053, 85.3% and 27.6% for Mu0083 and 93.3% and 50.1% for Mu0102, respectively. The names proposed for the new species are sp. nov. (Mu0050=ITM 501390=CCUG 77525), sp. nov. (Mu0053=ITM 501391=CCUG 77526), sp. nov. (Mu0083=ITM 501392=CCUG 77527) and sp. nov. (Mu0102=ITM 501393=CCUG 77528).

摘要

在丹麦哥本哈根国家血清研究所分枝杆菌学国际参考实验室的历史菌株收藏中发现了四种新型非结核分枝杆菌。对这些冻干分枝杆菌进行系统发育分析，结合16S、内部转录间隔区和23S元件，以及单拷贝核心基因（、、和）分析，这些分枝杆菌于1948年至1955年间从洗胃样本中临床分离得到，结果显示它们与地分枝杆菌和偶然分枝杆菌-母牛分枝杆菌进化枝内的模式菌株分组相关。表型特征、生化特性以及脂肪酸和分枝菌酸谱支持将其分类为新型菌株。通过计算平均核苷酸同一性和DNA:DNA杂交值，与最密切相关的模式菌株进行了基因组比较，结果显示Mu0050的平均核苷酸同一性和DNA:DNA杂交值分别为87.9%和33.0%，Mu0053为85.2%和27.4%，Mu0083为85.3%和27.6%，Mu0102为93.3%和5×0.1%。为新物种提议的名称分别是新种（Mu0050=ITM 501390=CCUG 77525）、新种（Mu0053=ITM 501391=CCUG 77526）、新种（Mu0083=ITM 501392=CCUG 77527）和新种（Mu0102=ITM 501393=CCUG 77528）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d37/11706282/cb3bda99ab92/ijsem-75-06620-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d37/11706282/375b4e40229e/ijsem-75-06620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d37/11706282/1028c28bdbb2/ijsem-75-06620-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d37/11706282/cb3bda99ab92/ijsem-75-06620-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d37/11706282/375b4e40229e/ijsem-75-06620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d37/11706282/1028c28bdbb2/ijsem-75-06620-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d37/11706282/cb3bda99ab92/ijsem-75-06620-g003.jpg

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