Byerley L O, Kirksey A
Am J Clin Nutr. 1985 Apr;41(4):665-71. doi: 10.1093/ajcn/41.4.665.
The influence of maternal intake of vitamin C on the vitamin C concentration in human milk and on the vitamin C intakes of breast-fed infants has not been demonstrated conclusively. This study examined these influences of diet and supplementation in 25 lactating women administered 90 mg of ascorbic acid for 1 day followed by 250, 500 or 1000 mg/day for 2 days or unsupplemented for 1 day followed by either 0 or 90 mg ascorbic acid supplement for 2 days. Vitamin C content in milk and urine was determined by the 2,4-dinitrophenylhydrazine method. Vitamin C intakes of infants were calculated from milk volume, as determined by the test-weighing method and from vitamin C levels in milk samples obtained at each feeding. Total maternal intakes of vitamin C, which exceeded 1000 mg/day or 10-fold the RDA for lactation (100 mg/day), did not significantly influence the vitamin C content in milk or the vitamin C intakes of infants. However, maternal vitamin C intake was positively correlated (r = 0.7) with maternal urinary excretion. These differences in milk and urine response to vitamin C intake suggest a regulatory mechanism for vitamin C levels in milk.
母亲摄入维生素C对母乳中维生素C浓度以及母乳喂养婴儿的维生素C摄入量的影响尚未得到确凿证实。本研究对25名哺乳期妇女进行了检测，她们先服用90毫克抗坏血酸1天，然后分别以250、500或1000毫克/天的剂量服用2天，或者先不补充1天，然后分别补充0或90毫克抗坏血酸2天，以此来研究饮食和补充剂的这些影响。采用2,4-二硝基苯肼法测定乳汁和尿液中的维生素C含量。根据试重法测定的奶量以及每次喂奶时采集的乳汁样本中的维生素C水平，计算婴儿的维生素C摄入量。母亲维生素C的总摄入量超过1000毫克/天或哺乳期推荐膳食摄入量（100毫克/天）的10倍，但并未对乳汁中的维生素C含量或婴儿的维生素C摄入量产生显著影响。然而，母亲的维生素C摄入量与母亲的尿排泄量呈正相关（r = 0.7）。乳汁和尿液对维生素C摄入量的这些差异表明存在一种调节乳汁中维生素C水平的机制。
