Venkataiah Venkata Suresh, Krithikadatta Jogikalmat, Teja Kavalipurapu Venkata, Mehta Deepak, Doble Mukesh
Department of Cariology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Department of Conservative Dentistry and Endodontics, Mamata Institute of Dental Sciences, Hyderabad, India.
Front Oral Health. 2025 Mar 12;6:1564838. doi: 10.3389/froh.2025.1564838. eCollection 2025.
Understanding the ion release behaviour of bioactive resin cements is essential for evaluating their potential in restorative dentistry. Sustained ion release, especially at cariogenic pH levels, can enhance remineralization and prolong the longevity of dental restorations. This study investigates the influence of pH on the ion release profiles of a bioactive resin cement before and after recharging.
Disk-shaped specimens ( = 15) of bioactive resin cement were prepared and exposed to three different pH conditions (4.5, 5.5, and 6.5) to simulate normal and cariogenic environments. Calcium ion release was quantified using atomic spectrophotometry, while fluoride and phosphate ions were analyzed using quantitative spectrophotometry. After an initial 30-day depletion phase, recharging was performed using casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF) paste.
In the pre-recharging phase (Stage 1), calcium ion release was more pronounced at acidic pH (4.5-5.5), particularly in the first five days. Fluoride and phosphate ions also demonstrated higher release at pH 4.5 and 5.5 compared to pH 6.5. Post-recharging (Stage 2) exhibited similar trends, emphasizing the role of regular recharge in sustaining ion availability. The absence of an initial burst release, commonly seen in other bioactive materials, suggests a distinct ion release mechanism in these resin cements.
The findings highlight the pH-dependent release characteristics of bioactive resin cements and reinforce the importance of recharging for maintaining their therapeutic potential. The unique release kinetics observed may offer advantages in long-term remineralization strategies for dental restorations.
了解生物活性树脂水门汀的离子释放行为对于评估其在牙体修复中的潜力至关重要。持续的离子释放，尤其是在致龋pH水平下，可增强再矿化并延长牙齿修复体的使用寿命。本研究调查了pH对生物活性树脂水门汀充电前后离子释放曲线的影响。
制备生物活性树脂水门汀的圆盘形标本（n = 15），并将其暴露于三种不同的pH条件（4.5、5.5和6.5）下，以模拟正常和致龋环境。使用原子分光光度法定量钙离子释放，同时使用定量分光光度法分析氟离子和磷酸根离子。在最初的30天耗尽期后，使用含氟酪蛋白磷酸肽 - 无定形磷酸钙（CPP - ACPF）糊剂进行充电。
在充电前阶段（第1阶段），酸性pH（4.5 - 5.5）下钙离子释放更为明显，尤其是在前五天。与pH 6.5相比，氟离子和磷酸根离子在pH 4.5和5.5时也表现出更高的释放。充电后（第2阶段）呈现出类似的趋势，强调了定期充电在维持离子可用性方面的作用。这些树脂水门汀中没有其他生物活性材料常见的初始突发释放，这表明其离子释放机制独特。
研究结果突出了生物活性树脂水门汀的pH依赖性释放特性，并强化了充电对于维持其治疗潜力的重要性。观察到的独特释放动力学可能为牙齿修复的长期再矿化策略提供优势。
