Fantel A G, Shepard T H, Newell-Morris L L, Moffett B C
Teratology. 1977 Feb;15(1):65-71. doi: 10.1002/tera.1420150109.
Daily oral administration of 10 mg/kg retinoic acid to pregnant Macaca nemestrina monkeys on days 20 to 44 resulted in a high frequency of craniofacial and musculoskeletal malformations. Craniofacial defects including cleft palate and anomalies of the prinna were common as were ectrodactyly, kyphosis, and muscular-joint contractures. Transposition of the great vessels of the heart occurred in one animal and polycystic kidney and associated urogenital anomalies in another. Shorter treatment periods with similar or higher dosages were not teratogenic and were less fetocidal. Although only relatively long treatment courses were teratogenic, the defects that resulted were morphologically similar to those induced with retinoic acid or other vitamin A compounds in other animal orders.
在妊娠第20至44天，每天给怀孕的猪尾猕猴口服10毫克/千克视黄酸，导致颅面和肌肉骨骼畸形的发生率很高。颅面缺陷包括腭裂和耳廓异常很常见，还有缺指（趾）畸形、脊柱后凸和肌肉关节挛缩。心脏大血管转位发生在一只动物身上，多囊肾和相关泌尿生殖系统异常发生在另一只动物身上。较短疗程使用相似或更高剂量时没有致畸作用，且杀胚胎作用较小。虽然只有相对较长的疗程有致畸作用，但所导致的缺陷在形态上与其他动物类群中视黄酸或其他维生素A化合物诱导产生的缺陷相似。
