对轮状病毒感染的补体结合抗体反应。
Complement-fixing antibody response to rotavirus infection.
作者信息
Gust I D, Pringle R C, Barnes G L, Davidson G P, Bishop R F
出版信息
J Clin Microbiol. 1977 Feb;5(2):125-30. doi: 10.1128/jcm.5.2.125-130.1977.
Abstract
A human rotavirus complement-fixing (CF) antigen, prepared by purification of large volumes of fluid feces collected from children with winter diarrhea, was used to study the development and persistence of antibody in children with diarrhea and the prevalence of rotavirus antibody in Melbourne. In children with diarrhea, antibody rises were detectable within 4 to 6 weeks of the onset of illness, and the titers usually remained elevated for the next 1 to 2 years. CF antibody did not develop in two children with proven rotavirus infection aged less than 6 months, an age at which poor CF responses to other viruses have also been observed. A study of CF antibody levels in the general community showed that in Melbourne, most children have been infected with human rotavirus by the age of 3 years.
摘要
通过纯化从患冬季腹泻的儿童收集的大量液体粪便制备的人轮状病毒补体结合（CF）抗原，用于研究腹泻儿童抗体的产生和持续情况以及墨尔本轮状病毒抗体的流行情况。在腹泻儿童中，发病后4至6周内可检测到抗体升高，并且滴度通常在接下来的1至2年内保持升高。两名年龄小于6个月且经证实感染轮状病毒的儿童未产生CF抗体，在这个年龄段对其他病毒的CF反应也较差。对普通人群CF抗体水平的一项研究表明，在墨尔本，大多数儿童在3岁时已感染人轮状病毒。
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