A Fluorescent Probe with Isovanillin-Containing Imidazole Backbone for Detecting Sulfite in Cellular Pulmonary Ventilation Protection Condition.

Herein, a fluorescent probe named IsoIm-SF with the isovanillin-containing imidazo backbone was developed for detecting sulfite in cellular pulmonary ventilation protection condition. In solution, the established pulmonary ventilation protection condition suggested no obvious impact on the detection. IsoIm-SF exhibited high sensitivity, long linear range, high steadiness, rapid response, high selectivity, and low cytotoxicity. In pulmonary cells, IsoIm-SF realized the imaging of both the exogenous and endogenous sulfite. Further, IsoIm-SF might monitor the sulfite level to indicate the pulmonary ventilation protection efficacy, including that contributed by the anesthetic treatment. This work was a challenging trial for establishing the anesthetic-related therapeutics to improve the methodology of the pulmonary ventilation protection.