Fahrenkrug J, Schaffalitzky de Muckadell O B
Eur J Clin Invest. 1977 Jun;7(3):201-3. doi: 10.1111/j.1365-2362.1977.tb01598.x.
The effect of infusing isotonic saline, isotonic and hypertonic glucose, fat emulsion, amino acids. ethanol, and hydrochloric acid into the duodenum on the plasma concentration of immunoreactive secretin was studied in seven normal subjects. Only hydrochloric acid showed any effect. After acidification of the duodenum with hydrochloric acid a significant rise in plasma secretin concentration was observed from 1.3 +/- 0.4 pmol X 1(-1) (mean +/- SEM) to a peak value of 13.0 +/- 1.2 pmol X 1(-1) after 5 min. The concentration returned to the basal level within 15 min. In eight other normal subjects the plasma secretin concentration was measured after the ingestion of a protein-rich meal. No significant changes were observed during the 2 h postprandial period.
在7名正常受试者中，研究了向十二指肠输注等渗盐水、等渗和高渗葡萄糖、脂肪乳剂、氨基酸、乙醇和盐酸对免疫反应性促胰液素血浆浓度的影响。只有盐酸显示出有任何作用。用盐酸使十二指肠酸化后，观察到血浆促胰液素浓度从1.3±0.4皮摩尔×升−1（平均值±标准误）显著升高，在5分钟后达到峰值13.0±1.2皮摩尔×升−1。浓度在15分钟内恢复到基础水平。在另外8名正常受试者中，在摄入富含蛋白质的餐后测量血浆促胰液素浓度。在餐后2小时内未观察到显著变化。
