Soubrane G, Canivet J, Coscas G
Int Ophthalmol. 1985 Nov;8(4):249-55. doi: 10.1007/BF00137653.
Previous reports have suggested that pregnancy does not influence the development of diabetic retinopathy. Since 1979 a prospective study using fluorescein angiography has been in progress. Preliminary results include 22 diabetic women with or without moderate background retinopathy studied until delivery. They were maintained under good metabolic control (mean HbA1: 7.68%). Five clinical and fluorescein angiography examinations were performed at prefixed intervals (before the 15th week, at the 28th and 35th weeks of pregnancy, and 6 and 15 months after delivery). The analysis of fluorescein angiography which did not induce any side effect showed that the mean number of microaneurysms increased from 42.7 before pregnancy to 56.7 at the 28th week and to 79.7 at the 35th week. Six months later the number was 62.7, and 15 months later 60.3, still higher than at the initial examination. This study suggests that pregnancy has an unfavourable influence on the background retinopathy in diabetic patients even when a good metabolic control is achieved and retinopathy is minimal.
以往的报告表明，妊娠不会影响糖尿病视网膜病变的发展。自1979年以来，一项使用荧光素血管造影的前瞻性研究一直在进行。初步结果包括对22名患有或未患有中度背景性视网膜病变的糖尿病女性进行研究，直至分娩。她们的代谢状况保持良好（平均糖化血红蛋白：7.68%）。在预定的时间间隔（妊娠第15周之前、妊娠第28周和第35周以及分娩后6个月和15个月）进行了五次临床和荧光素血管造影检查。对未产生任何副作用的荧光素血管造影分析表明，微动脉瘤的平均数量从妊娠前的42.7个增加到第28周时的56.7个，第35周时增加到79.7个。6个月后该数字为62.7个，15个月后为60.3个，仍然高于初次检查时的数量。这项研究表明，即使代谢状况良好且视网膜病变轻微，妊娠对糖尿病患者的背景性视网膜病变仍有不利影响。
