Adam D, Staber F, Belohradsky B H, Marget W
Infect Immun. 1972 Apr;5(4):537-41. doi: 10.1128/iai.5.4.537-541.1972.
The effect of the antibiotic dihydrostreptomycin on the phagocytic and bactericidal ability of peritoneal macrophages obtained from mice has been investigated. In subliminal concentrations which did not influence the bacterial growth, the drug caused macrophages to ingest and kill bacteria (Escherichia coli) at a higher rate than did macrophages without antibiotic. The differences for phagocytosis and intracellular killing of E. coli with and without a subliminal amount of dihydrostreptomycin were statistically significant. Macrophages pretreated with the antibiotic did not demonstrate any enhancement of phagocytosis.
已对抗生素双氢链霉素对从小鼠获得的腹腔巨噬细胞的吞噬和杀菌能力的影响进行了研究。在不影响细菌生长的阈下浓度下，该药物使巨噬细胞比未接触抗生素的巨噬细胞以更高的速率摄取和杀死细菌（大肠杆菌）。有无阈下量双氢链霉素时对大肠杆菌的吞噬作用和细胞内杀伤作用的差异具有统计学意义。用该抗生素预处理的巨噬细胞未表现出吞噬作用的增强。
