放射性标记的C3的代谢：兔体内激活的影响
Metabolism of radio-labelled C3: effects of in vivo activation in rabbits.
作者信息
Charlesworth J A, Williams D G, Naish P, Lachmann P J, Peters D K
出版信息
Clin Exp Immunol. 1974 Mar;16(3):445-52.
Abstract
Turnover studies were performed in rabbits using biologically screened, highly purified, radio-labelled human C3 and C3c. Experiments were also carried out using agents known to activate the complement system —cobra venom factor, human nephritic serum and nephrotoxic antibody to rabbit glomerular basement membrane. Activation of labelled C3 by cobra factor provided information regarding the metabolic behaviour of C3d. The fractional catabolic ratio (FCR) of human C3 in normal rabbits was 2·4–2·8% of the plasma pool per hr. FCR for C3c was 4.5% per hr. Activation of C3 consistently resulted in accelerated disappearance of plasma radioactivity. Analysis of the plasma and total body radioactivity curves indicated that both hypercatabolism and extravascular sequestration of radioactivity were responsible for this phenomenon.
摘要
利用经过生物学筛选的、高度纯化的、放射性标记的人C3和C3c，在兔身上进行了周转率研究。还使用已知能激活补体系统的试剂进行了实验，这些试剂包括眼镜蛇毒因子、人肾炎血清和抗兔肾小球基底膜的肾毒性抗体。眼镜蛇因子对标记C3的激活提供了有关C3d代谢行为的信息。正常兔中人C3的分解代谢分数率（FCR）为每小时血浆池的2.4 - 2.8%。C3c的FCR为每小时4.5%。C3的激活始终导致血浆放射性加速消失。对血浆和全身放射性曲线的分析表明，放射性的高分解代谢和血管外隔离都是造成这一现象的原因。
相似文献
1
Metabolism of radio-labelled C3: effects of in vivo activation in rabbits.放射性标记的C3的代谢：兔体内激活的影响
Clin Exp Immunol. 1974 Mar;16(3):445-52.
2
3
Delayed removal of renal-bound antigen in decomplemented rabbits with acute serum sickness.补体缺乏的急性血清病兔体内肾结合抗原的延迟清除
Clin Exp Immunol. 1978 May;32(2):199-206.
4
Studies in vivo of cobra factor and murine C3.眼镜蛇因子和小鼠补体C3的体内研究
Immunology. 1975 Feb;28(2):369-77.
5
6
Humoral immune system activity in inflammatory bowel disease.炎症性肠病中的体液免疫系统活性。
Scand J Gastroenterol. 1975;10(5):545-9.
7
Complement system in human colostrum: presence of nine complement components and factors of alternative pathway in human colostrum.人初乳中的补体系统：人初乳中存在九种补体成分及替代途径因子。
Int Arch Allergy Appl Immunol. 1977;54(5):428-33.
8
9
Changes in C3 metabolism during protozoan infection (Babesia rodhaini) in rats.
J Immunol. 1976 May;116(5):1284-8.
10
Complement dependence of localisation of aggregated IgG in germinal centres.生发中心中聚集IgG定位的补体依赖性
Scand J Immunol. 1975;4(4):343-47. doi: 10.1111/j.1365-3083.1975.tb02635.x.
引用本文的文献
1
The kinetics and distribution of C9 and SC5b-9 in vivo: effects of complement activation.体内C9和SC5b-9的动力学及分布：补体激活的影响
Clin Exp Immunol. 1995 Apr;100(1):40-6. doi: 10.1111/j.1365-2249.1995.tb03601.x.
2
Determination of the half-life of C3 in patients and its relation to the presence of C3-breakdown products and/or circulating immune complexes.测定患者体内C3的半衰期及其与C3裂解产物和/或循环免疫复合物存在情况的关系。
Rheumatol Int. 1982;2(4):161-6. doi: 10.1007/BF00286138.
3
Acute local inflammation alters synthesis, distribution, and catabolism of third component of complement (C3) in rabbits.急性局部炎症会改变家兔补体第三成分（C3）的合成、分布及分解代谢。
J Clin Invest. 1984 Aug;74(2):424-33. doi: 10.1172/JCI111438.
4
Metabolic studies of the third component of complement and the glycine-rich beta glycoprotein in patients with hypocomplementemia.低补体血症患者补体第三成分及富含甘氨酸的β糖蛋白的代谢研究。
J Clin Invest. 1974 Jun;53(6):1578-87. doi: 10.1172/JCI107708.
5
Isolation and analysis of complement activating aggregates from synovial fluid of patients with rheumatoid arthritis using monoclonal anti-C3d antibodies.使用单克隆抗C3d抗体从类风湿性关节炎患者滑液中分离并分析补体激活聚集体。
Ann Rheum Dis. 1987 Jan;46(1):55-64. doi: 10.1136/ard.46.1.55.
6
Complement (C3) metabolism in systemic lupus erythematosus in relation to the disease course.系统性红斑狼疮中补体（C3）代谢与疾病进程的关系
Rheumatol Int. 1986;6(5):221-6. doi: 10.1007/BF00541371.
7
Complement (C3) metabolism in rheumatoid arthritis in relation to the disease course.类风湿关节炎中补体（C3）代谢与疾病进程的关系。
Rheumatol Int. 1988;8(2):61-5. doi: 10.1007/BF00271836.
8
C3 metabolism in a patient with deficiency of the second component of complement (C2) and discoid lupus erythematosus.一名补体第二成分（C2）缺乏且患有盘状红斑狼疮患者的C3代谢
Clin Exp Immunol. 1976 May;24(2):238-48.
9
Metabolism of the fifth component of complement, and its relation to metabolism of the third component, in patients with complement activation.补体激活患者中补体第五成分的代谢及其与第三成分代谢的关系。
J Clin Invest. 1977 Apr;59(4):704-15. doi: 10.1172/JCI108689.
本文引用的文献
1
ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS.抗原-抗体交叉电泳
Anal Biochem. 1965 Feb;10:358-61. doi: 10.1016/0003-2697(65)90278-2.
2
The theory of tracer experiments with 131I-labelled plasma proteins.用131I标记血浆蛋白的示踪实验理论
Phys Med Biol. 1957 Jul;2(1):36-53. doi: 10.1088/0031-9155/2/1/305.
3
Alper CA, Rosen FS: Studies of the in vivo behavior of human C'3 in normal subjects and patients.阿尔珀·C·A、罗森·F·S：对正常受试者和患者体内人补体C3行为的研究。
J Clin Invest. 1967 Dec;46(12):2021-34. doi: 10.1172/JCI105691.
4
Two anticomplementary factors in cobra venom: hemolysis of guinea pig erythrocytes by one of them.眼镜蛇毒中的两种抗补体因子：其中一种可使豚鼠红细胞发生溶血。
J Immunol. 1969 Nov;103(5):944-52.
5
Chronic glomerulonephritis associated with low serum complement activity (chronic hypocomplementemic glomerulonephritis).伴有低血清补体活性的慢性肾小球肾炎（慢性低补体血症性肾小球肾炎）
Medicine (Baltimore). 1970 May;49(3):207-26. doi: 10.1097/00005792-197005000-00002.
6
Metabolism of third complement component (C3) in nephritis. Involvement of the classic and alternate (properdin) pathways for complement activation.肾炎中第三补体成分（C3）的代谢。补体激活的经典途径和替代（备解素）途径的参与。
N Engl J Med. 1972 Oct 26;287(17):835-40. doi: 10.1056/NEJM197210262871701.
7
Complement studies in membrano-proliferative glomerulonephritis.膜增生性肾小球肾炎的补体研究
Clin Exp Immunol. 1972 Jul;11(3):311-20.
8
Serum C'3 lytic system in patients with glomerulonephritis.肾小球肾炎患者的血清补体C3溶解系统
Science. 1969 Apr 25;164(3878):436-7. doi: 10.1126/science.164.3878.436.
9
A method of trace iodination of proteins for immunologic studies.一种用于免疫学研究的蛋白质微量碘化方法。
Int Arch Allergy Appl Immunol. 1966;29(2):185-9. doi: 10.1159/000229699.
10
Role of C3b in the breakdown of C3 in hypocomplementaemic mesangiocapillary glomerulonephritis.C3b在低补体血症性系膜毛细血管性肾小球肾炎中C3分解代谢中的作用
Lancet. 1973 Mar 3;1(7801):447-9. doi: 10.1016/s0140-6736(73)91877-1.
Zotero 插件