Henderson L L, Larson J B, Gleich G J
J Allergy Clin Immunol. 1975 Jan;55(1):10-5. doi: 10.1016/s0091-6749(75)80003-0.
Patients allergic to ragweed pollen who did not receive immunotherapy had an increase in ragweed-specific IgE antibodies associated with seasonal exposure. Of 17 such patients, 15 reached peak levels between mid-September and mid-October. Two had peak values after mid-October; the levels were only slightly higher than earlier values. Our study shows that serum obtained in mid-October reflects approximately the maximal IgE antibody level attained 0y ragweed-sensitive patients in our area and that this value can be used as a baseline in monitoring the subsequent decline in antibodies. In addition, our data support an earlier observation that the magnitude of seasonal rise in IgE antibody is related to the preseasonal value. The significantly positive correlation of the results of carefully performed skin tests (end point titration) with radioallergosorbent test (RAST) values suggests the possibility that the RAST can be employed as a reliable diagnostic aid, perhaps even replacing the skin test.
未接受免疫疗法的豚草花粉过敏患者，其豚草特异性IgE抗体水平会随着季节性接触而升高。在17名此类患者中，15名在9月中旬至10月中旬达到峰值水平。两名患者在10月中旬之后达到峰值；其水平仅略高于早期值。我们的研究表明，10月中旬采集的血清大致反映了我们地区豚草敏感患者所达到的最大IgE抗体水平，并且该值可作为监测抗体随后下降情况的基线。此外，我们的数据支持了早期的一项观察结果，即IgE抗体季节性升高的幅度与季前值有关。精心进行的皮肤试验（终点滴定）结果与放射变应原吸附试验（RAST）值之间存在显著正相关，这表明RAST有可能用作可靠的诊断辅助手段，甚至可能取代皮肤试验。
