酿酒酵母中甲硫氨酰转运核糖核酸细胞含量与甲硫氨酸酶合成之间的关系。
Relationship between methionyl transfer ribonucleic acid cellular content and synthesis of methionine enzymes in Saccharomyces cerevisiae.
作者信息
Surdin-Kerjan Y, Cherest H, Robichon-Szulmajster H
出版信息
J Bacteriol. 1973 Mar;113(3):1156-60. doi: 10.1128/jb.113.3.1156-1160.1973.
Abstract
Derepression of some methionine biosynthetic enzymes (methionine group I enzymes) obtained in methionine limitation has been found to be accompanied by a significant lack of in vivo charging of bulk methionine transfer ribonucleic acid (tRNA(Met)) and in addition by a decreased rate of synthesis of all tRNAs. Under the same conditions, methionyl-tRNA synthetase (MTS) was derepressed rather than repressed. These results are in agreement with those previously published based on studies of a mutant with an impaired MTS (5) and reinforce the idea that the rate of synthesis of methionine group I enzymes can be related to the total content of methionyl (Met)-tRNA (Met) per cell. They also render unlikely that MTS could be a constituent of the regulatory signal.
摘要
在蛋氨酸限制条件下获得的一些蛋氨酸生物合成酶（第一组蛋氨酸酶）的去阻遏，已被发现伴随着大量蛋氨酸转运核糖核酸（tRNA(Met)）在体内显著缺乏充电，此外还伴随着所有tRNA合成速率的降低。在相同条件下，甲硫氨酰-tRNA合成酶（MTS）被去阻遏而非被抑制。这些结果与先前基于对MTS受损的突变体的研究发表的结果一致（5），并强化了这样一种观点，即第一组蛋氨酸酶的合成速率可能与每个细胞中甲硫氨酰（Met）-tRNA（Met）的总含量有关。它们还使得MTS不太可能成为调节信号的组成部分。
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Methionine-mediated repression in Saccharomyces cerevisiae: a pleiotropic regulatory system involving methionyl transfer ribonucleic acid and the product of gene eth2.酿酒酵母中蛋氨酸介导的阻遏作用：一种涉及甲硫氨酰转移核糖核酸和eth2基因产物的多效调节系统。
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