Smith J L, Murphy B L, Auslander M O, Maynard J E, Schalm S S, Summerskill W H, Gitnick G L
Gastroenterology. 1976 Aug;71(2):208-9.
Sera from well individuals, including controls and asymptomatic HBsAg carriers, post-transfusion hepatitis cases, and chronic active liver disease patients were examined for the presence of "e" antigen and e antibody by rheophoresis. Our data confirm the specific association between the e determinant and hepatitis B infections and indicate that e antigen is closely associated with evidence of chronic hepatic dysfunction, in contrast to the association of e antibody with hepatic normalcy in HBsAg carriers. However, these correlations are not absolute and, therefore, it should not be inferred that all e antigen-positive individuals will develop chronic hepatitis nor, conversely, that presence of e antibody invariably protects against the development of chronic hepatitis.
通过电流电泳法检测了健康个体（包括对照组、无症状乙肝表面抗原携带者、输血后肝炎病例以及慢性活动性肝病患者）血清中“e”抗原和e抗体的存在情况。我们的数据证实了e决定簇与乙型肝炎感染之间的特定关联，并表明e抗原与慢性肝功能障碍的证据密切相关，这与HBsAg携带者中e抗体与肝脏正常状态的关联形成对比。然而，这些相关性并非绝对，因此，不应推断所有e抗原阳性个体都会发展为慢性肝炎，反之亦然，即e抗体的存在并不一定能预防慢性肝炎的发生。
