Ebina T, Sato A, Umezu K, Aso H, Ishida N, Seki H, Tsukamoto T, Takase S, Hoshi S, Ohta M
Med Microbiol Immunol. 1984;173(2):87-93. doi: 10.1007/BF02124822.
Previous virological and immunological studies have suggested that multiple sclerosis (MS) is an auto-immune disease triggered by a virus infection. In order to inhibit the growth of measles virus in the patient's jejunum, we obtained an IgA-rich cow colostrum containing anti-measles lactoglobulin resistant to proteases. This colostrum was orally administered to patients with MS to investigate its effect on the course of the disease. Measles-positive antibody colostrum was orally administered every morning to 15 patients with MS at a daily dosage of 100 ml for 30 days. Similarly, measles-negative antibody (less than 8) control colostrum was orally administered to 5 patients. As a clinical assessment, disability scores developed by the International Federation of Multiple Sclerosis Societies were used. As a result, of 7 high NT titre (512-5120) anti-measles colostrum recipients 5 patients improved and 2 remained unchanged. Among 8 low NT titre (8-32) anti-measles colostrum recipients 5 patients improved and 3 remained unchanged. However, of 5 negative NT titre (less than 8) colostrum recipients 2 patients remained unchanged and 3 worsened. No side-effects were observed in colostrum recipients. These findings suggest the efficacy of orally administered anti-measles colostrum in improving the condition of MS patients (P less than 0.05).
以往的病毒学和免疫学研究表明，多发性硬化症（MS）是一种由病毒感染引发的自身免疫性疾病。为了抑制麻疹病毒在患者空肠中的生长，我们获取了一种富含IgA且含有抗麻疹乳球蛋白（对蛋白酶具有抗性）的牛初乳。将这种初乳口服给予MS患者，以研究其对病程的影响。每天早晨给15例MS患者口服含麻疹阳性抗体的初乳，每日剂量为100毫升，持续30天。同样，给5例患者口服含麻疹阴性抗体（小于8）的对照初乳。作为临床评估，采用了国际多发性硬化症协会制定的残疾评分。结果，在7例高NT滴度（512 - 5120）抗麻疹初乳接受者中，5例患者病情改善，2例保持不变。在8例低NT滴度（8 - 32）抗麻疹初乳接受者中，5例患者病情改善，3例保持不变。然而，在5例NT滴度阴性（小于8）初乳接受者中，2例患者病情保持不变，3例病情恶化。初乳接受者未观察到副作用。这些发现表明口服抗麻疹初乳对改善MS患者病情有效（P小于0.05）。
