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针对轮状病毒不同抗原决定簇的单克隆抗体。

Monoclonal antibodies directed against different antigenic determinants of rotavirus.

作者信息

Lambert J P, Marbehant P, Marissens D, Zissis G

出版信息

J Virol. 1984 Jul;51(1):47-51. doi: 10.1128/JVI.51.1.47-51.1984.

DOI:10.1128/JVI.51.1.47-51.1984
PMID:6202884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254397/
Abstract

We have developed a series of monoclonal antibodies against the calf strain RIT 4237 (subgroup 1) and the human strain 82-561 (subgroup 3) of rotavirus, both grown in tissue culture, and also against the human rotavirus 81-2162 (subgroup 2), extracted from a fecal specimen. A variety of different specificities was observed among these antibodies, namely, antibodies against group and subgroup determinants, as well as neutralizing antibodies. By using monoclonal antibodies against the subgroup antigen in an enzyme-linked immunoassay system, the constant predominance of subgroup 2 viruses in humans was confirmed in 74 stools collected from children in Brussels who suffered a diarrheal illness between July 1981 and June 1983. The availability of these antibodies also made it possible to improve the sensitivity and the specificity of the test system.

摘要

我们已经研制出一系列单克隆抗体，分别针对在组织培养中生长的小牛轮状病毒株RIT 4237（第1亚组）和人轮状病毒株82 - 561（第3亚组），以及从粪便标本中提取的人轮状病毒81 - 2162（第2亚组）。在这些抗体中观察到了多种不同的特异性，即针对组和亚组决定簇的抗体以及中和抗体。通过在酶联免疫测定系统中使用针对亚组抗原的单克隆抗体，在1981年7月至1983年6月期间从布鲁塞尔患腹泻病的儿童收集的74份粪便中，证实了第2亚组病毒在人类中始终占主导地位。这些抗体的可用性还使得提高检测系统的灵敏度和特异性成为可能。

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