Lammi-Keefe C J, Hammerschmidt D E, Weisdorf D J, Jacob H S
Inflammation. 1982 Sep;6(3):227-34. doi: 10.1007/BF00916404.
Manipulation of dietary fatty acid content has been shown to influence platelet aggregation responses. Because granulocytes and platelets interact in a variety of biologic systems, we wondered whether a similar effect might be observed on granulocytes. Granulocyte function was therefore studied in three donors prior to and after three weeks upon a diet supplemented with large amounts of eicosapentaenoic acid. The previously reported attenuation of platelet aggregation was observed, but no effect was seen on granulocyte aggregation, chemotaxis, or superoxide production. Although several other explanations are possible, we suggest that the most likely explanation for this dichotomy is that granulocyte aggregation and chemotaxis are not centrally dependent upon production of thromboxane A.
饮食中脂肪酸含量的调控已被证明会影响血小板聚集反应。由于粒细胞和血小板在多种生物系统中相互作用，我们想知道对粒细胞是否可能观察到类似的效应。因此，在三位供体摄入大量二十碳五烯酸的饮食三周前后，对其粒细胞功能进行了研究。观察到了先前报道的血小板聚集减弱的情况，但未发现对粒细胞聚集、趋化性或超氧化物生成有影响。尽管可能有其他几种解释，但我们认为这种二分法最可能的解释是，粒细胞聚集和趋化性并不主要依赖于血栓素A的产生。
