完整的c-mos（大鼠）核苷酸序列：c-mos蛋白中保守结构域的存在
Complete c-mos (rat) nucleotide sequence: presence of conserved domains in c-mos proteins.
作者信息
van der Hoorn F A, Firzlaff J
出版信息
Nucleic Acids Res. 1984 Feb 24;12(4):2147-56. doi: 10.1093/nar/12.4.2147.
Recently we described the isolation of c-mos (rat). The gene belongs to the family of oncogenes. Some facts render c-mos unique among the oncogenes : a) it does not contain intervening sequences and b) its expression was never detected in a large number of normal mouse tissues examined. We undertook the sequence analysis of c-mos (rat) in order to compare it to the nucleotide sequences published for c-mos (mouse), c-mos (human), c-src and bovine protein kinase. c-mos (rat) contains an open reading frame of 1017 nucleotides, coding for a polypeptide of 339 amino acids. c-mos (rat)-makes use of the same ATG that defines the N-terminus of the c-mos (human) protein. By comparing all c-mos sequences available we found sequences with high mutational rates to be confined to certain domains. This comparison, together with data on the biological activities of the cloned DNA, allowed us to tentatively define regions involved in (a) function(s) of c-mos other than transformation.
最近我们描述了c-mos（大鼠）的分离。该基因属于癌基因家族。一些事实使c-mos在癌基因中独具特色：a）它不包含间隔序列；b）在大量检测的正常小鼠组织中从未检测到其表达。我们对c-mos（大鼠）进行了序列分析，以便将其与已发表的c-mos（小鼠）、c-mos（人类）、c-src和牛蛋白激酶的核苷酸序列进行比较。c-mos（大鼠）包含一个1017个核苷酸的开放阅读框，编码一个由339个氨基酸组成的多肽。c-mos（大鼠）使用与定义c-mos（人类）蛋白N端相同的ATG。通过比较所有可用的c-mos序列，我们发现高突变率的序列局限于某些结构域。这种比较，连同关于克隆DNA生物学活性的数据，使我们能够初步确定c-mos除转化功能外其他功能所涉及的区域。
Zotero 插件