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相似文献

1
Complete c-mos (rat) nucleotide sequence: presence of conserved domains in c-mos proteins.完整的c-mos（大鼠）核苷酸序列：c-mos蛋白中保守结构域的存在
Nucleic Acids Res. 1984 Feb 24;12(4):2147-56. doi: 10.1093/nar/12.4.2147.
2
Mouse c-mos oncogene activation is prevented by upstream sequences.小鼠c-mos癌基因的激活受到上游序列的抑制。
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7817-21. doi: 10.1073/pnas.81.24.7817.
3
Molecularly cloned c-mos(rat) is biologically active.分子克隆的c-mos（大鼠）具有生物活性。
EMBO J. 1982;1(11):1313-7. doi: 10.1002/j.1460-2075.1982.tb01316.x.
4
Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.通过内源性脑池内A颗粒基因组的插入激活小鼠浆细胞瘤中的c-mos癌基因。
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7118-22. doi: 10.1073/pnas.80.23.7118.
5
A novel transposon-like repeat interrupted by an LTR element occurs in a cluster of B1 repeats in the mouse c-mos locus.一种被LTR元件中断的新型转座子样重复序列出现在小鼠c-mos基因座的B1重复序列簇中。
Nucleic Acids Res. 1984 Nov 26;12(22):8381-92. doi: 10.1093/nar/12.22.8381.
6
Chicken homolog of the mos proto-oncogene.
Mol Cell Biol. 1988 Feb;8(2):923-9. doi: 10.1128/mcb.8.2.923-929.1988.
7
[Regions of human genome containing analogs of oncogenes and retrovirus genes. I. A family of c-mos genes and unusual structure of ORA-gp5 locus].
Mol Biol (Mosk). 1984 Jan-Feb;18(1):60-82.
8
Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element.通过DNA重排激活细胞癌基因：类插入序列元件的可能作用
Nature. 1982 Dec 16;300(5893):607-11. doi: 10.1038/300607a0.
9
The complete nucleotide sequence of the rat 18S ribosomal RNA gene and comparison with the respective yeast and frog genes.大鼠18S核糖体RNA基因的完整核苷酸序列及其与相应酵母和青蛙基因的比较。
Nucleic Acids Res. 1983 Jul 25;11(14):4879-90. doi: 10.1093/nar/11.14.4879.
10
Oncogenic activation of murine mos protein kinase by DNA rearrangement of its N-terminal coding region.通过其N端编码区的DNA重排实现鼠源mos蛋白激酶的致癌激活。
Oncogene. 1992 Feb;7(2):331-8.

引用本文的文献

1
Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.Mos 3'非翻译区的调控差异是卵母细胞成熟过程中Mos mRNA胞质多聚腺苷酸化和翻译募集的物种特异性时间模式的基础。
Mol Reprod Dev. 2008 Aug;75(8):1258-68. doi: 10.1002/mrd.20877.
2
Rates of evolution of the retroviral oncogene of Moloney murine sarcoma virus and of its cellular homologues.莫洛尼氏鼠肉瘤病毒逆转录病毒癌基因及其细胞同源物的进化速率。
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4198-201. doi: 10.1073/pnas.82.12.4198.
3
Genomic structure of the cottontail rabbit (Shope) papillomavirus.棉尾兔（肖普）乳头瘤病毒的基因组结构。
Proc Natl Acad Sci U S A. 1985 Mar;82(6):1580-4. doi: 10.1073/pnas.82.6.1580.
4
Sequences upstream of c-mos(rat) that block RNA accumulation in mouse cells do not inhibit in vitro transcription.在小鼠细胞中阻止RNA积累的c-mos（大鼠）上游序列不抑制体外转录。
Mol Cell Biol. 1985 Feb;5(2):406-9. doi: 10.1128/mcb.5.2.406-409.1985.
5
The repressor sequence upstream of c-mos acts neither as polyadenylation site nor as transcription termination region.c-mos上游的阻遏物序列既不作为聚腺苷酸化位点，也不作为转录终止区域。
Nucleic Acids Res. 1986 Nov 25;14(22):8771-83. doi: 10.1093/nar/14.22.8771.
6
v-mos proteins encoded by myeloproliferative sarcoma virus and its ts159 mutant.由骨髓增殖性肉瘤病毒及其ts159突变体编码的v-mos蛋白。
J Virol. 1992 Feb;66(2):1267-72. doi: 10.1128/JVI.66.2.1267-1272.1992.

本文引用的文献

1
Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis.正常细胞序列转化潜能的激活：肿瘤发生的分子模型。
Science. 1981 May 22;212(4497):941-3. doi: 10.1126/science.7233190.
2
In vitro methylation of specific regions of the cloned Moloney sarcoma virus genome inhibits its transforming activity.克隆的莫洛尼氏肉瘤病毒基因组特定区域的体外甲基化会抑制其转化活性。
Mol Cell Biol. 1983 Mar;3(3):305-14. doi: 10.1128/mcb.3.3.305-314.1983.
3
Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene.内源性病毒长末端重复序列与插入激活的细胞癌基因中的序列之间的同源性。
Nature. 1983 Apr 7;302(5908):547-8. doi: 10.1038/302547a0.
4
DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster.与脊椎动物癌基因同源的DNA序列在黑腹果蝇中是保守的。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6789-92. doi: 10.1073/pnas.78.11.6789.
5
P85gag-mos encoded by ts110 Moloney murine sarcoma virus has an associated protein kinase activity.由ts110莫洛尼氏鼠肉瘤病毒编码的P85gag-mos具有相关的蛋白激酶活性。
Proc Natl Acad Sci U S A. 1983 Jan;80(2):412-6. doi: 10.1073/pnas.80.2.412.
6
Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.人类c-onc基因的完整核苷酸序列：人类c-fos蛋白的推导氨基酸序列。
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3183-7. doi: 10.1073/pnas.80.11.3183.
7
The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein.莫洛尼氏鼠肉瘤病毒的转化蛋白是一种可溶性细胞质蛋白。
Cell. 1983 May;33(1):161-72. doi: 10.1016/0092-8674(83)90345-8.
8
Cellular oncogenes and retroviruses.细胞癌基因与逆转录病毒。
Annu Rev Biochem. 1983;52:301-54. doi: 10.1146/annurev.bi.52.070183.001505.
9
Molecularly cloned c-mos(rat) is biologically active.分子克隆的c-mos（大鼠）具有生物活性。
EMBO J. 1982;1(11):1313-7. doi: 10.1002/j.1460-2075.1982.tb01316.x.
10
Kilo-sequencing: creation of an ordered nest of asymmetric deletions across a large target sequence carried on phage M13.千碱基测序：在噬菌体M13携带的大目标序列上创建一系列有序的不对称缺失嵌套。
Methods Enzymol. 1983;101:98-122. doi: 10.1016/0076-6879(83)01008-3.

完整的c-mos（大鼠）核苷酸序列：c-mos蛋白中保守结构域的存在

Complete c-mos (rat) nucleotide sequence: presence of conserved domains in c-mos proteins.

作者信息

van der Hoorn F A, Firzlaff J

出版信息

Nucleic Acids Res. 1984 Feb 24;12(4):2147-56. doi: 10.1093/nar/12.4.2147.

DOI:10.1093/nar/12.4.2147
PMID:6322135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC318647/
Abstract

Recently we described the isolation of c-mos (rat). The gene belongs to the family of oncogenes. Some facts render c-mos unique among the oncogenes : a) it does not contain intervening sequences and b) its expression was never detected in a large number of normal mouse tissues examined. We undertook the sequence analysis of c-mos (rat) in order to compare it to the nucleotide sequences published for c-mos (mouse), c-mos (human), c-src and bovine protein kinase. c-mos (rat) contains an open reading frame of 1017 nucleotides, coding for a polypeptide of 339 amino acids. c-mos (rat)-makes use of the same ATG that defines the N-terminus of the c-mos (human) protein. By comparing all c-mos sequences available we found sequences with high mutational rates to be confined to certain domains. This comparison, together with data on the biological activities of the cloned DNA, allowed us to tentatively define regions involved in (a) function(s) of c-mos other than transformation.

摘要

最近我们描述了c-mos（大鼠）的分离。该基因属于癌基因家族。一些事实使c-mos在癌基因中独具特色：a）它不包含间隔序列；b）在大量检测的正常小鼠组织中从未检测到其表达。我们对c-mos（大鼠）进行了序列分析，以便将其与已发表的c-mos（小鼠）、c-mos（人类）、c-src和牛蛋白激酶的核苷酸序列进行比较。c-mos（大鼠）包含一个1017个核苷酸的开放阅读框，编码一个由339个氨基酸组成的多肽。c-mos（大鼠）使用与定义c-mos（人类）蛋白N端相同的ATG。通过比较所有可用的c-mos序列，我们发现高突变率的序列局限于某些结构域。这种比较，连同关于克隆DNA生物学活性的数据，使我们能够初步确定c-mos除转化功能外其他功能所涉及的区域。