合成佐剂活性胞壁酰肽对体内骨髓生成的调节：集落刺激活性的诱导及干细胞增殖的刺激
Modulation of myelopoiesis in vivo by synthetic adjuvant-active muramyl peptides: induction of colony-stimulating activity and stimulation of stem cell proliferation.
作者信息
Galelli A, Chedid L
出版信息
Infect Immun. 1983 Dec;42(3):1081-5. doi: 10.1128/iai.42.3.1081-1085.1983.
Abstract
Modulation of myelopoiesis by three synthetic muramyl peptides was investigated in vivo. Two adjuvant-active compounds (N-acetylmuramyl dipeptide [MDP] and MDP-butyl-ester) elicited significant responses in DBA/2 mice characterized by a rise in the level of monocyte-macrophage colony-stimulating activity in serum, a proliferation of multipotential stem cells in the bone marrow, and an expansion of granulocyte-macrophage progenitors in the spleen. In contrast, the adjuvant-inactive stereoisomer MDP(D-D) induced only low levels of circulating colony-stimulating activity. Thus, MDP or MDP-butyl-ester injection could induce a greater number of macrophages and therefore enhance both specific and nonspecific immunity.
摘要
在体内研究了三种合成的胞壁酰肽对骨髓生成的调节作用。两种具有佐剂活性的化合物（N-乙酰胞壁酰二肽 [MDP] 和 MDP-丁酯）在 DBA/2 小鼠中引发了显著反应，其特征为血清中单核细胞-巨噬细胞集落刺激活性水平升高、骨髓中多能干细胞增殖以及脾脏中粒细胞-巨噬细胞祖细胞扩增。相比之下，无佐剂活性的立体异构体 MDP(D-D) 仅诱导出低水平的循环集落刺激活性。因此，注射 MDP 或 MDP-丁酯可诱导产生更多巨噬细胞，从而增强特异性和非特异性免疫。
相似文献
1
Modulation of myelopoiesis in vivo by synthetic adjuvant-active muramyl peptides: induction of colony-stimulating activity and stimulation of stem cell proliferation.合成佐剂活性胞壁酰肽对体内骨髓生成的调节：集落刺激活性的诱导及干细胞增殖的刺激
Infect Immun. 1983 Dec;42(3):1081-5. doi: 10.1128/iai.42.3.1081-1085.1983.
2
Induction of colony-stimulating factor and stimulation of stem cell proliferation by injection of muroctasin.
Arzneimittelforschung. 1988 Jul;38(7A):980-3.
3
Induction of tumoricidal macrophages and production of cytokines by synthetic muramyl dipeptide analogues.
Vaccine. 1988 Jun;6(3):238-44. doi: 10.1016/0264-410x(88)90218-6.
4
Stimulation of human endothelial cells by synthetic muramyl peptides: production of colony-stimulating activity (CSA).合成的胞壁酰肽对人内皮细胞的刺激作用：集落刺激活性（CSA）的产生。
Exp Hematol. 1985 Dec;13(11):1157-63.
5
Modulation of natural killer activity by muramyl peptides: relationship with adjuvant and anti-infectious properties.胞壁酰肽对自然杀伤活性的调节：与佐剂及抗感染特性的关系。
Nat Immun Cell Growth Regul. 1987;6(2):65-76.
6
Effect of MDP-Lys(L18), a derivative of MDP, on enhancing host resistance against Hantaan virus infection in newborn mice.MDP衍生物MDP-Lys（L18）对增强新生小鼠抗汉坦病毒感染宿主抵抗力的作用。
Vaccine. 1995 Oct;13(14):1300-5. doi: 10.1016/0264-410x(95)00041-x.
7
8
In vitro and in vivo effects of MDP-Lys(L18) on mouse megakaryocyte progenitor cells (CFU-Meg).MDP-Lys(L18) 对小鼠巨核细胞祖细胞（CFU-Meg）的体外和体内作用
Exp Hematol. 1992 May;20(4):517-22.
9
Production of colony-stimulating factor from macrophages by muroctasin.
Arzneimittelforschung. 1988 Jul;38(7A):983-6.
10
Macrophage stimulation in vitro by an inactive muramyl dipeptide derivative after conjugation to a multi-poly(DL-alanyl)-poly(L-lysine) carrier.与多聚（DL-丙氨酰）-聚（L-赖氨酸）载体偶联后，一种无活性的胞壁酰二肽衍生物在体外对巨噬细胞的刺激作用。
Infect Immun. 1980 Apr;28(1):1-5. doi: 10.1128/iai.28.1.1-5.1980.
引用本文的文献
1
Anti-neoplastic and immunomodulatory potency of co-treatment based on bovine lactoferrin and/or muramyl dipeptide in tumor-bearing mice.基于牛乳铁蛋白和/或胞壁酰二肽联合治疗对荷瘤小鼠的抗肿瘤和免疫调节效力。
Toxicol Res (Camb). 2020 Apr 24;9(2):137-147. doi: 10.1093/toxres/tfaa012. eCollection 2020 Apr.
2
Effect of muramyl peptides on mitochondrial respiration.胞壁酰肽对线粒体呼吸的影响。
Clin Exp Immunol. 2009 Jan;155(1):72-8. doi: 10.1111/j.1365-2249.2008.03794.x.
3
4
Some cellular and pathophysiological correlates of the inflammatory effects of a synthetic immunomodulatory agent, muramyl dipeptide (MDP).一种合成免疫调节剂胞壁酰二肽（MDP）炎症效应的一些细胞和病理生理学关联。
Agents Actions. 1993 Jan;38(1-2):106-15. doi: 10.1007/BF02027221.
5
Colony-stimulating activity induced by synthetic muramyl peptides: variation with chemical structure and association with anti-infectious activity.合成胞壁酰肽诱导的集落刺激活性：随化学结构的变化及与抗感染活性的关联
Infect Immun. 1984 Nov;46(2):495-500. doi: 10.1128/iai.46.2.495-500.1984.
6
Marked enhancement in vivo of adjuvant activity of muramyl dipeptide to protein antigens and to synthetic weak immunogens with monoclonal anti-muramyl dipeptide antibodies.用单克隆抗胞壁酰二肽抗体在体内显著增强胞壁酰二肽对蛋白质抗原和合成弱免疫原的佐剂活性。
Infect Immun. 1985 Aug;49(2):312-9. doi: 10.1128/iai.49.2.312-319.1985.
7
Soluble non-cross-linked peptidoglycan polymers stimulate monocyte-macrophage inflammatory functions.可溶性非交联肽聚糖聚合物可刺激单核细胞-巨噬细胞的炎症功能。
Infect Immun. 1985 Sep;49(3):731-41. doi: 10.1128/iai.49.3.731-741.1985.
8
9
Role of macrophages in serum colony-stimulating factor induction by Lactobacillus casei in mice.巨噬细胞在干酪乳杆菌诱导小鼠血清集落刺激因子中的作用。
Infect Immun. 1988 Feb;56(2):357-62. doi: 10.1128/iai.56.2.357-362.1988.
10
Immunomodulatory and therapeutic properties of FK-565 in mice.FK-565在小鼠体内的免疫调节及治疗特性
Cancer Immunol Immunother. 1989;28(2):93-100. doi: 10.1007/BF00199108.
本文引用的文献
1
A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.正常小鼠骨髓细胞辐射敏感性的直接测量。
Radiat Res. 1961 Feb;14:213-22.
2
Muramyl dipeptide stimulation of particle clearance in several animal species.胞壁酰二肽对几种动物物种中颗粒清除的刺激作用。
J Reticuloendothel Soc. 1980 Nov;28(5):457-71.
3
Effect of bestatin and muramyl-dipeptide on macrophage-bound aminopeptidase.
Hoppe Seylers Z Physiol Chem. 1981 May;362(5):563-8.
4
Stimulatory effect of N-acetyl Muramyl dipeptide in vivo: proliferation of bone marrow progenitor cells in mice.N-乙酰胞壁酰二肽在体内的刺激作用：小鼠骨髓祖细胞的增殖
Infect Immun. 1982 Aug;37(2):452-62. doi: 10.1128/iai.37.2.452-462.1982.
5
Apyrogenic, adjuvant-active N-acetylmuramyl-dipeptides.无热原性、佐剂活性的N-乙酰胞壁酰二肽。
J Med Chem. 1982 Jan;25(1):87-90. doi: 10.1021/jm00343a018.
6
Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity.一种无致热原性的新型合成胞壁酰肽佐剂的生物活性。
Infect Immun. 1982 Feb;35(2):417-24. doi: 10.1128/iai.35.2.417-424.1982.
7
Common pattern of two distinct types of colony-stimulating factor in human tissues and cultured cells.人类组织和培养细胞中两种不同类型集落刺激因子的常见模式。
J Clin Invest. 1980 Mar;65(3):772-5. doi: 10.1172/JCI109726.
8
Effect of endotoxin on granulopoiesis and colony-stimulating factor.内毒素对粒细胞生成和集落刺激因子的影响。
N Engl J Med. 1972 Feb 3;286(5):227-32. doi: 10.1056/NEJM197202032860502.
9
Acute antigen-induced elevation of serum colony stimulating factor (CFS) levels.急性抗原诱导的血清集落刺激因子（CFS）水平升高。
Immunology. 1971 Sep;21(3):427-36.
10
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.细菌肽聚糖衍生物佐剂活性的最小结构要求。
Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317-25. doi: 10.1016/0006-291x(74)90458-6.
Zotero 插件