Galelli A, Chedid L
Infect Immun. 1983 Dec;42(3):1081-5. doi: 10.1128/iai.42.3.1081-1085.1983.
Modulation of myelopoiesis by three synthetic muramyl peptides was investigated in vivo. Two adjuvant-active compounds (N-acetylmuramyl dipeptide [MDP] and MDP-butyl-ester) elicited significant responses in DBA/2 mice characterized by a rise in the level of monocyte-macrophage colony-stimulating activity in serum, a proliferation of multipotential stem cells in the bone marrow, and an expansion of granulocyte-macrophage progenitors in the spleen. In contrast, the adjuvant-inactive stereoisomer MDP(D-D) induced only low levels of circulating colony-stimulating activity. Thus, MDP or MDP-butyl-ester injection could induce a greater number of macrophages and therefore enhance both specific and nonspecific immunity.
在体内研究了三种合成的胞壁酰肽对骨髓生成的调节作用。两种具有佐剂活性的化合物（N-乙酰胞壁酰二肽 [MDP] 和 MDP-丁酯）在 DBA/2 小鼠中引发了显著反应，其特征为血清中单核细胞-巨噬细胞集落刺激活性水平升高、骨髓中多能干细胞增殖以及脾脏中粒细胞-巨噬细胞祖细胞扩增。相比之下，无佐剂活性的立体异构体 MDP(D-D) 仅诱导出低水平的循环集落刺激活性。因此，注射 MDP 或 MDP-丁酯可诱导产生更多巨噬细胞，从而增强特异性和非特异性免疫。
